Exam #1 Varcolis Ch. 11, 15 ATI 11-13, 21 And 22 Pharm Pgs. 51-66 Flashcards

1
Q

Causes of depression

A

Triggers
Genetics
Biochemical
Learned helplessness
Cultural

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2
Q

Major Depressive Disorder

A

Episodic 2-3 months
suicidal thoughts
-constant state of being unhappy
-psychomotor retardation (slow moving)
-appetite changes
-can’t focus
-sleep disturbance
-energy decreased
-They can’t function in certain areas of life

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3
Q

Persistent depressive disorder

A

Starts at adolescents
Hard to distinguish
Daytime fatigue
Irritable
Able to function but not optimal
Eating excessively or not enough
Pessimistic thinking
Low self-esteem

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4
Q

Assessment for Depression

A

Hypothyroidism and vitamin D deficiency can both mimic depression
Cognition and thought content- what is their concentration like?
Suicide and homicide assessment
Previous episodes of depression and coping skills
Ask “what does depression mean to you?”

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5
Q

Depression outcomes

A

Safety should always be priority
Example outcomes
-patient will name 2 persons of support when suicidal
-patient will gain 5 lbs
-patient will sleep 6-8 hours per night

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6
Q

Implementation

A

Therapeutic silence
Offering self
Precautionary measures for suicide
Ask patient what is their plan if suicidal
Have a one to one sitter- should not be alone, no harmful items when suicidal
Safety contract- ask for a promise to not overdose

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7
Q

Interdisciplinary treatments

A

Milieu therapy
Psychotherapy
Mindfulness based cognitive therapy
Group therapy

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8
Q

Antidepressant drugs

A

SSRIs
SNRIs
Trazadone
TCAs
MAOIs
Bupropion

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9
Q

SSRIs

A

Citalopram
Escitalopram
Fluoxetine
Paroxetine
Sertraline

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10
Q

SSRIs Uses

A

Depression with anxiety
Panic disorder
PTSD
OCD
Bulimia

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11
Q

SSRIs side effects

A

Sleep disturbance
Sexual dysfunction
Tension headaches
Reduced appetite
Hyponatremia
Rash/SJS

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12
Q

SSRIs Adverse Effects

A

Serotonin Syndrome
Shivering
Hyperreflexia
Increased temperature
Vital sign instability: Increase BP
Encephalopathy
Restlessness
Sweating
Abdominal pain
Increased bleeding tendencies

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13
Q

SSRIs contraindications

A

Ulcer
GI bleeding

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14
Q

SNRIs

A

Venlafaxine
Desvenlafaxine
Duloxetine
Levomilnacipran

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15
Q

SNRIs Uses

A

Major depressive disorder
Anxiety disorder

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16
Q

SNRIs Adverse effects

A

Serotonin syndrome
Hyponatremia

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17
Q

Trazadone uses

A

Adjunct therapy for depression
Insomnia

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18
Q

Tricyclics (TCAs)

A

Amitriptyline
Doxepin
Impipramine
Nortriptyline

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19
Q

Tricyclics (TCAs)

A

Anticholinergic side effects
Dry mouth
Blurred vision
Tachycardia
Constipation
Urinary retention
Esophageal reflux
Photophobia
Sexual dysfunction

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20
Q

Tricyclics (TCAs) Adverse effects

A

Orthostatic hypotension
Dysrhythmias
Myocardial infarction
Heart block

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21
Q

TCAs Contraindications

A

Recent MI
Narrow angle glaucoma
Benign prostatic
Hypertrophy
Seizures
Pregnancy

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22
Q

Monoamine oxidase inhibitors (MAOIs)

A

Phenelzine
Tranylcypromine
Isocarboxazid
Selegiline

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23
Q

MAOIs adverse effects

A

Hypertensive crisis
Severe HA or blurry vision
Chest pain, tachycardia
SOB
Diaphoresis, anxiety
Mental status change
Confusion
N/V

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24
Q

MAOIs foods to avoid

A

Avocados, figs
Fermented, smoked, cured meats, and fish
Bologna, pepperoni, salami
Almost all cheeses
Yeast extract
Some beers
Protein supplements
Shrimp paste, soy sauce

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25
MAOIs contraindications
Cardiovascular disease HTN, CHF Liver disease Recurrent headaches Recent surgery
26
Bupropion
Depression Smoking cessation Prevention of seasonal pattern depression Weight loss
27
Bupropion Adverse effects
Appetite suppression Seizures
28
Ketamine Uses
Anesthetic: can be given to aggressive pts Postpartum depression Takes away suicidal ideation
29
Ketamine side effects
Increased BP, HR Dissociation (high out of body experience)
30
Light therapy
For mild depression
31
St. John’s Wort
Interact with all antidepressants - potentially fatal serotonin syndrome can result if combined with SSRIs
32
Electroconvulsive therapy Uses
Major depressive disorder Schizophrenia Acute Mania
33
Electroconvulsive therapy
A last resort Inducing seizures
34
ECT medications
Atropine: decrease secretions so they don’t aspirate Propofol: puts them to sleep Succinylcholine: stops jerking movement
35
Anxiety
A feeling of uneasiness, uncertainty, or dread Results from a real or perceived threat Source of threat is unknown or unrecognized.
36
Fear
Reaction to a specific danger You see the threat
37
Normal anxiety
Can motivate you to do things
38
Acute anxiety
Example: anxious right before getting surgery
39
Pathological anxiety
Emotional response that is out of proportion to the threat Emotional response can continue even after the threat is resolved.
40
Levels of anxiety
Mild Moderate Severe Panic
41
Mild anxiety
Ability to learn: good Physical characteristics -restless -mild irritability -nail biting/finger tapping -shaking their leg
42
Moderate
Ability to learn: altered but still possible Physical characteristics -tension -pounding heart -increased. Respiratory rate and heart rate -somatic symptoms: using the restroom a lot -voice tremors
43
Severe anxiety
Overly focused Scattered details Ability to learn: unable Physical characteristics: -automatic behavior -severe somatic symptoms (chest pain) -hyperventilation -sense of dread
44
Panic anxiety
Ability to learn: unable Characteristics: -erratic and impulsive behavior (ex: may take off all their clothes) -hallucinations -pass out -dissociate -freeze
45
Panic disorders
Recurrent and unexpected panic attacks **monitor for suicide, don’t leave pt alone** Benzodiazepines: help during panic attacks Anticipatory anxiety: worry a panic attack is going to happen Symptoms: Nausea, hot flashes
46
Panic attack
Can last between 1-30 min Sudden onset of fear or apprehension not always in response to an acute stressor
47
Social anxiety disorder
Provoked by exposure to a social situation or a performance situation Fear is being evaluated or rejected: embarrassment or humiliation
48
Agoraphobia
Fear of being in places where help might not be available **escape might be difficult or embarrasing** Ex: a grocery store, a park, fear of crowd Treatment therapy: SSRIs
49
Generalized anxiety disorder
Excessive anxiety and worry about a number or events and activities Constant “what ifs” Treatment: combo of meds and therapy
50
OCD
Obsessions: uncontrollable, recurring thoughts Compulsions: ritualistic behaviors Ex: washing hands 3 times *important to allow them to carry out their rituals, never interrupt*
51
Body dysmorphic disorder
Imagined “defective body part” Ex: constantly looking at themselves in the mirror, grooming themselves
52
Hoarding disorder
Excessive collecting of items Persistent difficulty in parting with possessions
53
Acceptance and commitment therapy
Part of psychotherapy Commit to changing their behavior
54
Meditation
55
Mindfulness
Focusing on different parts of the body Ex: yoga
56
Behavioral therapy
Aversion therapy: focuses on pain, given an undesirable stimulus ex: the pedophile example Flooding: throwing someone in a situation with the considered threat Systematic desensitization Exposure and response prevention Modeling: holding a cricket to show there is no harm Thought stopping
57
Relaxation training
Deep breathing Guided imagery Progressive relaxation Autogenic training Self-hypnosis Biofeedback-assisted relaxation
58
Antidepressants
SSRIs SNRIs - Long term treatments -start with low doses -prioritize suicide risk
59
Benzodiazepines
Lorazepam Clonazepam Alprazolam
60
Benzodiazepines uses
Short term treatment Tolerance develops Withdrawal symptoms Addiction — sedation —used for the treatment of relief of anxiety and reduce seizures
61
Benzodiazepines side effects
Amnesia: memory loss — avoid driving — impaired judgment Long term use can lead to dementia and respiratory depression
62
Benzodiazepines antidote
Flumazenil
63
Antihistamines
Diphenhydramine Hydroxyzine
64
Antihistamine uses
Short term use only Good for those with substance use disorder Sedating: therefore helping with anxiety and tension
65
Buspirone
Non-additive Long term treatment 2-4 weeks to be effective **Only for long term treatment of anxiety** Can cause orthostatic hypotension, lightheadedness, and dizziness
66
Kava kava
Elevates mood and feeling of relaxation Used for the treatment of anxiety and insomnia
67
Valerian
Best for sleep Treatment of anxiety and relieve insomnia
68
Lavender oil
**most effective** Boost mood and treat sleep
69
St. John’s wort
Treatment of depression, anxiety and insomnia