Exam #1 Varcolis Ch. 11, 15 ATI 11-13, 21 And 22 Pharm Pgs. 51-66 Flashcards
Causes of depression
Triggers
Genetics
Biochemical
Learned helplessness
Cultural
Major Depressive Disorder
Episodic 2-3 months
suicidal thoughts
-constant state of being unhappy
-psychomotor retardation (slow moving)
-appetite changes
-can’t focus
-sleep disturbance
-energy decreased
-They can’t function in certain areas of life
Persistent depressive disorder
Starts at adolescents
Hard to distinguish
Daytime fatigue
Irritable
Able to function but not optimal
Eating excessively or not enough
Pessimistic thinking
Low self-esteem
Assessment for Depression
Hypothyroidism and vitamin D deficiency can both mimic depression
Cognition and thought content- what is their concentration like?
Suicide and homicide assessment
Previous episodes of depression and coping skills
Ask “what does depression mean to you?”
Depression outcomes
Safety should always be priority
Example outcomes
-patient will name 2 persons of support when suicidal
-patient will gain 5 lbs
-patient will sleep 6-8 hours per night
Implementation
Therapeutic silence
Offering self
Precautionary measures for suicide
Ask patient what is their plan if suicidal
Have a one to one sitter- should not be alone, no harmful items when suicidal
Safety contract- ask for a promise to not overdose
Interdisciplinary treatments
Milieu therapy
Psychotherapy
Mindfulness based cognitive therapy
Group therapy
Antidepressant drugs
SSRIs
SNRIs
Trazadone
TCAs
MAOIs
Bupropion
SSRIs
Citalopram
Escitalopram
Fluoxetine
Paroxetine
Sertraline
SSRIs Uses
Depression with anxiety
Panic disorder
PTSD
OCD
Bulimia
SSRIs side effects
Sleep disturbance
Sexual dysfunction
Tension headaches
Reduced appetite
Hyponatremia
Rash/SJS
SSRIs Adverse Effects
Serotonin Syndrome
Shivering
Hyperreflexia
Increased temperature
Vital sign instability: Increase BP
Encephalopathy
Restlessness
Sweating
Abdominal pain
Increased bleeding tendencies
SSRIs contraindications
Ulcer
GI bleeding
SNRIs
Venlafaxine
Desvenlafaxine
Duloxetine
Levomilnacipran
SNRIs Uses
Major depressive disorder
Anxiety disorder
SNRIs Adverse effects
Serotonin syndrome
Hyponatremia
Trazadone uses
Adjunct therapy for depression
Insomnia
Tricyclics (TCAs)
Amitriptyline
Doxepin
Impipramine
Nortriptyline
Tricyclics (TCAs)
Anticholinergic side effects
Dry mouth
Blurred vision
Tachycardia
Constipation
Urinary retention
Esophageal reflux
Photophobia
Sexual dysfunction
Tricyclics (TCAs) Adverse effects
Orthostatic hypotension
Dysrhythmias
Myocardial infarction
Heart block
TCAs Contraindications
Recent MI
Narrow angle glaucoma
Benign prostatic
Hypertrophy
Seizures
Pregnancy
Monoamine oxidase inhibitors (MAOIs)
Phenelzine
Tranylcypromine
Isocarboxazid
Selegiline
MAOIs adverse effects
Hypertensive crisis
Severe HA or blurry vision
Chest pain, tachycardia
SOB
Diaphoresis, anxiety
Mental status change
Confusion
N/V
MAOIs foods to avoid
Avocados, figs
Fermented, smoked, cured meats, and fish
Bologna, pepperoni, salami
Almost all cheeses
Yeast extract
Some beers
Protein supplements
Shrimp paste, soy sauce
MAOIs contraindications
Cardiovascular disease
HTN, CHF
Liver disease
Recurrent headaches
Recent surgery
Bupropion
Depression
Smoking cessation
Prevention of seasonal pattern depression
Weight loss
Bupropion Adverse effects
Appetite suppression
Seizures