Exam 1 Study--Adrenergic Drug Receptors Flashcards
Name the receptor for this drug: Epinephrine
Alpha at high dose, beta at low dose
Name the receptor for this drug: Norepinephrine
Alpha
Name the receptor for this drug: Dopamine
Alpha1 at high dose (vasoconstriction) and beta1 at low dose (cardiac stimulation); D1 (renal vasodilation), D2 (blocks NE release presynaptically)
Name the receptor for this drug: Isoproterenol
Beta1 and beta2
Name the type of drug, what type of receptor it stimualtes (if applicable), its primary use(s) and/or actions, and anything else significant about it: Fenoldopam
Alpha2 (moderate) and D1 (vasodilation)
Name the receptor for this drug: Dobutamine
Beta1
Name the receptor for this drug: Oxymetazoline
Alpha1 and alpha2
Name the receptor for this drug: Phenylephrine
Alpha1
Name the receptor for this drug: Clonidine
Alpha2
Name the receptor for this drug: Metaproterenol
Beta2
Name the receptor for this drug: Albuterol
Beta2
Name the receptor for this drug: Terbutaline
Beta2
Name the receptor for this drug: Salmeterol
Beta2
Name the receptor for this drug: Formoterol
Beta2
Name the receptor for this drug: Ephedrine
Alpha and beta
Name the receptor for this drug: Pseudoephedrine
Alpha and beta
Name the receptor for this drug: Phenoxybenzamine
Alpha1 and alpha2 blocker
Name the receptor for this drug: Phentolamine
Alpha1 and alpha2 blocker
Name the receptor for this drug: Prazosin
Alpha1 blocker
Name the receptor for this drug: Terazosin
Alpha1 blocker
Name the receptor for this drug: Doxazosin
Alpha1 blocker
Name the receptor for this drug: Tamsulosin
Alpha1A blocker
Name the receptor for this drug: Alfuzosin
Alpha1 blocker
Name the receptor for this drug: Yohimbine
Alpha2 blocker
In general, what are beta blockers used for?
Treating angina, arrhythmias, myocaridla infarction, heart failure, hyperthyroidism, glaucoma, and prophlylactic migraine. They lower blood pressure, but they do not cause postural hypotension due to alpha receptors being spared.
Name the receptor for this drug: Propanolol
Beta1 and beta2 blocker
Name the receptor for this drug: Timolol
Beta1 and beta2 blocker
Name the receptor for this drug: Nadolol
Beta1 and beta2 blocker
Why are beta1 blockers sometimes preferable to nonselective beta blockers?
They eliminated any unwanted bronchoconstrictor effects.
Name the receptor for this drug: Acebutolol
Acebutolol is actually a partial agonist of beta1 and beta2 but is said to be an antagonist because it inhibits stimulation by the more potent endogenous catecholamines, epinephrine and norepinephrine.
Name the receptor for this drug: Atenolol
Beta1 blocker
Name the receptor for this drug: Bisoprolol
Beta1 blocker
Name the receptor for this drug: Betaxolol
Beta1 blocker
Name the receptor for this drug: Nebivolol
Beta1 blocker
Name the receptor for this drug: Esmolol
Beta1 blocker
Name the receptor for this drug: Pindolol
Pindolol is actually a partial agonist of beta1 and beta2 but is said to be an antagonist because it inhibits stimulation by the more potent endogenous catecholamines, epinephrine and norepinephrine.
Name the receptor for this drug: Labetalol
Alpha and beta blocker
Name the receptor for this drug: Carvedilol
Alpha and beta blocker
What are the major effects mediated by alpha1 receptors?
Vasoconstriction, increased peripheral resistance, increased blood pressure, mydriasis, increased closure of internal sphincter of the bladder (urinary retention).
What are the major effects mediated by alpha2 receptors?
Located presynaptically, they cause inhibition of NE release, inhibition of ACh release, inhibition of insulin release.
What are the major effects mediated by beta1 receptors?
Tachycardia, increased lipolysis (for energy), increased myocardial contractility, increased release of renin (to increase BP).
What are the major effects mediated by beta2 receptors?
Vasodilation (to get blood to muscles), decreased peripheral resistance, bronchodilation, increased muscle and liver glycogenolysis (for energy), increased release of glucagon, relaxed uterine smooth muscle.
