EXAM #1: CLINICAL ASPECTS OF OVARIAN CANCER Flashcards
What is the most important independent risk factor in ovarian cancer?
Age
What should work-up of an adenxal mass include?
1) B-hCG
2) TVUS
What do you need to remember about timing for a TVUS in the menstrual cycle?
Don’t do in the luteal phase–Corpus Luteum will give a false positive
What finding on an ultrasound would be indicative of adnexal cancer?
1) Excresences
2) Ascites
3) Mural nodules
What should you check on any patient that has abnormal uterine bleeding?
B-hCG
What imaging study is best to evaluate the pelvic organs?
Ultrasound
Endometrial biopsy shows endometrial proliferation. What does this mean?
Patient is in follicular phase
Histologically, what is pathognomonic for a granulosa cell tumor?
Call Exner Bodies
What labs can be checked for evaluate for recurrence of a Granulosa Tumor?
Inhibin A and Inhibin B
What tumor marker is associated with epithelial ovarian cancer?
CA-125
What tumor markers are assocaited with malignant germ-cell tumors?
B-hCG
LDH
AFP
What tumor markers are associated with embryonal carcinaoma?
AFP
B-hCG
What tumor markers is associated with endodermal sinus tumor?
AFP
What is the most common type of ovarian cancer?
Epithelial
What is the treatment for Epithelial Ovarian Cancer?
1) Cytoreductive therapy
2) Chemotherapy
What is the Carbo MOA?
Binds and cross-links DNA; prevents DNA synthesis
What is the Taxol MOA?
Binds stable microtubules, inhibiting cell division
What are the symptoms of a molar pregnancy?
1) Size of uterus does not match menstrual dates
2) Elevated B-hCG
3) Toxemia i.e. pre-eclampsia prior to 24 weeks
4) Hyperemesis
What is the imaging modality of choice for a molar pregnancy?
US
What percentage of molar pregnancies are invasive?
5-10%
How should you work-up a molar pregnancy?
1) CXR
2) CBC, CMP, clotting studies
How do you treat a molar pregnancy?
1) Evacuation
2) B-hCG
3) Chemotherapy (as needed)
What is the major complicaiton associated with evacuation of a molar pregnancy?
Massive hemorrhage
What do you want to ensure after evacuation of molar pregnancy?
Negative B-hCG levels
