Exam 1 Flashcards
what are the layers of the skin from deep to superficial?
- stratum basale
- stratum spinosum
- stratum granulosum
- stratum lucidum
- stratum corneum
what layers of the epidermis are composed of living keratinocytes?
the first 3 layers
How many layers make up the stratum basale?
1 layer of cuboidal to low columnar cells
what are the 3 cell types found in the stratum basale
keratinocytes, melanocytes, and tactile cells
what are the most abundant cells in the epidermis?
keratinocytes
what is the function and location of keratinocytes
found in all layers, keratinocytes divide to regenerate new cells replacing old cells shed at surface, synthesizes keratin
what is the function of melanocytes
produce and store pigment in response to UV light, transfer pigment granules into keratinocytes
what is the function of tactile cells and what is another name for them
tactile (merkel) cells are scattered within stratum basale and are sensitive to touch. When compressed, chemicals are released that stimulate sensory nerve endings
how many layers make up the stratum spinosum
several layers of polygonal keratinocytes
what is the function of the stratum spinosum?
daughter cells from stratum basale are pushed in and begin to develop into specialized non dividing keratinocytes
what is the function of langerhans cells and where can they be found?
(epidermal dendritic cells) initiate immune response, found in spinosum and granulosum
how many layers make up the stratum granulosum
3-5 layers of keratinocytes
describe the steps of keratinization
(begins in granulosum)
- keratinocytes fill with keratin
- causes nucleus and organelles to disintergrate
- fully keratinized cell dead but structurally sound
- takes several layers to complete
how many layers is the stratum lucidum?
2-3 translucent layers
which layer of epidermis is only found in thick skin?
stratum lucidum
what is the protein found in thick skin that protects it from UV light?
eleidin
how many layers make up the stratum corneum?
20-30 layers of dead, interlocking keratinized cells
how long does it take the keratinocytes to migrate from the stratum basale to the stratum corneum?
about 2 weeks
what is the difference between thick skin and thin skin?
thick skin lacks hair follicles and sebaceous glands
true or false, those with darker skin have more melanocytes
false, everyone has the same number of melanocytes
where does carotene accumulate in the skin?
in subcutaneous fat and the keratinocytes of the stratum corneum
what causes albinism?
enzyme for melanin is nonfunctional and melanin can’t be produced
what is a nevus?
a localized overgrowth of melanocytes (a mole)
what do freckles represent?
localized areas of increased melanocyte activity
what is a hemangioma and what are the 2 types?
a skin discoloration due to benign blood vessel tumor, 2 types: capillary and cavernous