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May14 Oral Histology > EX2; Dentin/Pulp Complex 1 > Flashcards

EX2; Dentin/Pulp Complex 1 Flashcards

1
Q

This the soft connective tissue in the tooth center with blood vessels and whole cells

A

pulp

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2
Q

Is the pulp mineralized or non-mineralized

A

non-mineralized

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3
Q

This is the mineralized connective tissue covering the pulp with no blood vessels or whole cells

A

dentin

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4
Q

What two things does dentin contain in the tubules

A

odontoblastic process

nerve endings

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5
Q

What is the main clinical significance of dentin

A

protective of both enamel and pulp

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6
Q

This feature of the DEJ facilitates adhesion

A

scalloping

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7
Q

When does dentinogenesi begin

A

during the bell stage

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8
Q

Just prior to dentinogenesis, what occurse

A

tissues layers of dental organ present
crown outline present
no odontoblasts or ameloblasts

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9
Q

In which part of the tooth germ does dentinogenesis begin

A

the most coronal portion

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10
Q

Where does the inductive signal for odontoblast differentiation come from

A

the enamel organ

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11
Q

What is the main signaling molecule/growth factor controlling odontogenesis

A

Wnt10a

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12
Q

This is a signaling molecule that follows Wnt10a; is induced by this

A

dentin/odontoblast specific marker; DSPP

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13
Q

The odontoblast secretes this first then it is mineralized

A

organic matrix then its mineralized

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14
Q

What is the name of the unmineralized organic matrix of dentin

A

predentin

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15
Q

What are the requirements for mineralization

A

Ca2+ and phosphate

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16
Q

Where does the phosphate come from used for mineralization

A

from plasma and cleavage of organic containing phosphate transported into dentin through and between odontoblasts

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17
Q

What are the two sections of crystal formation

A

mantle

circumpulpal

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18
Q

What is the principal component of the organic matrix of mantle dentin

A

collagen type 1

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19
Q

What are the sizes of the collagen fibrils in mantle dentin

A

relatively large

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20
Q

What is the orientation of the mantle dentin fibrils

A

at right angles to the basal lamina/future DEJ

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21
Q

Near the end of mantle dentin formation, what occurs

A

one dentin process becomes dominant

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22
Q

What is different about the circumpulpal dentin compared to mantle dentin

A

smaller fibrils

parallel to basal lamina

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23
Q

Where does the mineralization come from in circumpulpal dentin

A

not matrix vesicles, it comes from proteins

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24
Q

What is circumpulpal dentin synthesized from

A

synthesized and secreted from odontoblastic process (along with ions)

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25
Q

Special properties of the proteins involved in circumpulpal dentin formation

A

they precipitate Ca2+ ions preset in the interstitial fluid, initiate crystal formation

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26
Q

Which dentin is more organic

A

mantle dentin

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27
Q

Which dentin is more mineralized

A

circumpulpal dentin

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28
Q

The DEJ is more vulnerable to what

A

caries

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29
Q

How specific is phosphophoryn/dentin phosphoprotein

A

relatively specific to dentin

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30
Q

What is the prominent dentinal protein

A

> 50% non-collagenous proteins (NCPs)

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31
Q

What constitutes to the negative charge of phosphophoryn/dentin phosphoprotein

A

highly phosphyorlated
high in serine/aspartic acid
acidic/anionic

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32
Q

What is the percentage of organic, inorganic, and water of dentin by WEIGHT

A 
inorganc = 70% (HA)
organic = 20%
water = 10%
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33
Q

What is the percentage of organic, inorganic, and water of dentin by VOLUME

A 
inorganic = 45%
organic = 33%
water = 22%
34
Q

What is the only physical property that dentin is greater than enamel at

A

compressive strength

35
Q

What is orientation of the hydroxyapatite crystals

A

random orientation

36
Q

What makes up the extracellular matrix of the organic phase of dentin

A

collagen

non-collagenous proteins

37
Q

What are the non-tissue specific proteins that make up the organic phase of dentin

A

proteoglycans

signaling molecules/growth factors; bone morphogenetic protein

38
Q

What are the mineralized-tissue specific proteins that make up the organic phase of dentin

A

osteoclastin

bone sialprotein

39
Q

What are the dentin dominant proteins that make up the organic phase of dentin

A

dentin matrix protein 1
dentin glycoprotein
dentin sialoprotein

40
Q

What type of long chain does dentin phosphoprotein contain

A

polar amino acid repeats
greater than 200 serine-serine-aspartic acid
phosphorylated serines

41
Q

What would occur is DSPP is mutated (abnormal)

A

it cannot be released from the odontoblast; stick in the rER or cell membrane

42
Q

What are the changes at the genetic level from a D1 mutation in DSPP

A

changes in the first three amino acids; iso, pro, val

43
Q

Is the D1 DSPP mutation dominant or recessive inheritance

A

dominant

44
Q

What is the result in the coding region of DSPP under a D1 mutation

A

small base pair deletions that produce frame shifts changing the polar amino acid repeats to uncharged

45
Q

mutates DSPP also affects the normal protein made by the cell how

A

by trapping it

46
Q

What type of mutation is D1 DSPP

A

dominant negative

47
Q

What is the result if a cell begins to have more DSPP mutatnts

A

less DSPP is secreted

48
Q

What are the contents of the dentinal tubules

A 
fluid; major component = water
nerve fibers
odontoblastic processes
less collagen fibers
non-cellular lining sheath although organic composition is unknown
49
Q

How are the dentinal tubules in relation to the DEJ

A

at right angles

50
Q

What is the shape of the dentinal tubules

A

S-shaped at the crown

straighter in the root

51
Q

What type of branching pattern does the dentinal tubules have

A

terminal and lateral branches

52
Q

Does inner or outer dentin contain more tubules

A

inner dentin

53
Q

What is the pattern of depth in the dentin

A

the number continues to decrease in outer dentin

deep > middle > outer

54
Q

Does inner or outer dentin contain larger tubules

A

the diameter of tubules is larger in inner dentin

55
Q

Where do the tubules occupy less surface area, at the DEJ or the P-D border

A

DEJ

56
Q

What increases toward the P-D border

A

permeability and wetness

57
Q

This dentin formed until the completion of root development

A

primary dentin

58
Q

True or False

primary dentin does not comprise most of the dentin

A

False; it does

59
Q

What are the two types of primary dentin

A

mantle

circumpulpal

60
Q

Which is more mineralized, mantle or circumpulpal dentin

A

circumpulpal

61
Q

This dentin forms after root development and is formed at a slower rate but throughout life

A

secondary dentin

62
Q

Where is secondary dentin in relation to primary dentin

A

central

63
Q

What are the similarities between primary and secondary dentin

A

similar in structure

also classified as circumpulpal dentin

64
Q

This dentin is produced in specific locations in response to noxious stimulus

A

tertiary dentin

65
Q

What is the structure of tertiary dentin

A

structurally irregular
may or may not have tubules
may include cells

66
Q

Where is both intertubular and intratubular dentin found

A

in primary and secondary dentin

67
Q

Where is intertubular and intratubular dentin found in relation to the tubules

A 
inter = between
intra = lining
68
Q

Does intertubular or intratubular have a greater volume

A

inter

69
Q

Does intertubular or intratubular have more mineralization

A

intra

70
Q

Which; intertubular or intratubular, is a ring wider near the DEJ; accounting for narrowing of tubule

A

intra

71
Q

This type of dentin is when the tubules are completely filled with intra/peritubular dentin

A

translucent or sclerotic dentin

72
Q

This type of dentin is a normal process of aging

A

translucent

73
Q

This type of dentin is accelerated deposition due to caries or attrition

A

sclerotic

74
Q

This is when the tubules dry out and become filled with air

A

dead tracts

75
Q

This is hypo mineralized dentin just below mantle dentin

A

interglobular dentin

76
Q

The initial mineralization of dentin occurs in what

A

descrete foci

77
Q

The individual foci can undergo calcification and become what

A

calcospherites; eventually fuse

78
Q

If the individual foci do not calcify, what happens

A

becomes interglobular dentin

79
Q

This is prominent in the crown

A

Tomes’ granular layer

80
Q

Where is there much interglobular dentin present

A

in DSPP knockout mice

81
Q

Growth lines in dentin represent what

A

incremental pattern of deposition

May14 Oral Histology (25 decks)

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