Evolution of the Inflammatory Periodontal Lesion Flashcards
Neutrophils make up __________ of cells that cross the blood vessel to enter ____________
- 1st wave
- inflammtory site
What are the 7 types of responses by Neutrophils?
1) Rolling
2) Margination
3) Adhesion/Binding
4) Emigration/Diapedesis
5) Migration/Chemotaxis
6) Phagocytosis
7) Killing/Neutralization of Antigen
What do the Basophil/Mast cell cytoplasmic granules contain?
1) Histamine (causes vasodilation & increased vascular permeability(
2) Platelet activating factor
3) Heparin (anticoag)
4) TNF-alpha
5) Slow secreting substance of anaphylaxis (SRS-As)
- Leukotriene C4, D4, and E4
What are the major functions of Macrophages?
1) Phagocytosis
2) Antigen recognition
3) Synthesis & release of cytokines & lymphokines
What is IL-1?
Stimulates osteoclasts, fibroblasts, macrophages, and activation of CD 8 lymphocytes
Pro-inflammatory
What is IL-6?
Stimulates B & T cells
Pro-inflammatory
What is TNF-alpha?
activator of endothelium/osteoclasts & inflammatory mediator
Pro-inflammatory
What is INF?
Interferon- interferes w/ virus replication
What are lipid mediators of inflammation?
Prostaglandins, leukotrienes, and platelet activating factor (PAF)
What is a CD4 Lymphocyte?
- Helper cell that is KEY to immune response
- Actives macrophages
- Activates CD8 (cytotoxic) T lymphocytes
- Activates B-Lymphocytes to secrete immunoglobulin
What is CD 8 Lymphocytes?
-(Cytotoxic) T lymphocytes that destroys target cells by synthesis and release of cytotoxin, e.g., perforin & granzymes
Cytotoxins= _________
Lymphokines
CD8 synthesize and release what?
- Interfeon gamma (INF- gamma)
- Tumor necrosis Factor alpha (TNF-a)
- Tumor necrosis Facor-beta (TNF-b)
B-lymphocytes is a precursor of ________
Plasma cells
Plasma cells and B-lymophocytes are capable of synthesis and release of what?
Immunoglobulin
Ig G, M, E, D and A
What are the Cellular Population at different stages of inflammation?
Initial–> PMNs
Acute–> PMNs, Macrophages, and some lymphocytes
Chronic–> A few PMNs & macrophages, and MOSTLY lymphocytes and Plasma cells
What is a abscess defined as?
- A dense localized collection of inflammatory cells, primarily PMNs and tea necrosis.
- With time the accumulation of inflammatory cells are surrounded & walled off by immature connective tissue & proliferating capillaries
What are the vascular components of gingiva; inhalation?
1) Color
2) Edema/Swelling
3) Bleeding
What is the difference between Perio and Gingivitis?
GINGIVITIS- requires plaque to initiate disease and clinical signs of inflammation. (NO bone loss, PDL destruction of apical migration of JE)
PERIODONTITIS- requires plaque, bone loss, PDL destruction, apical migration of JE, BUT may NOT require signs of INFLAMMATION
Everyone with poor plaque control develops _______
gingivitis
T or F. Everyone that has gingivitis because of poor long-term plaque control eventually develops periodontitis.
FALSE
T or F. Plaque is necessary and sufficient to initiate periodontitis.
False (not sufficient)
T or F. Plaque is necessary and sufficient to initiate gingivitis.
True
T or F. Development of periodontitis requires a susceptible host
True
What are the two common microbiota associated with health?
Facultative and Gram (+)
What are the two common microbiota associated with Periodontitis?
Anaerobes and Gram (-)
T or F. Everbody develops gingivitis but only susceptible patients will develop periodontitis
True
What is the positive and negative affect of our Immune System?
Positive- Provides a defensive process
Negative- Accounts for tissue injury observed in gingivitis and periodontitis
What is was the study conducted in Sri-Lanka?
- No dental treatment
- No plaque control
- 100% gingivitis
- 81 % Moderate Alveolar bone loss rate
- 8% rapid rate
- 11 % no progression
Periodontitis is similar to gingivitis in that ___________
It is Plaque- induced
Periodontitis is subject related int that a _______ is required
Susceptible host (immune system)
In Periodontitis, only a ______ % of the population experiences ________
- Small
- Advanced destruction
In Periodontitis the progression of the disease is probably an ________________ model
Asynchronous multiple burst model
What is a continuous model?
ALL sites show a continuous an progressive loss of CAL over time