Ethylene-glycol & drugs Flashcards
Metabo of ethylene-glycol
Ethylene-glycol -> glycoaldehyde -> glycolic -> glycoxylic -> oxalic acid -> Ca oxalate
Which spe is the most sensitive to ethylene-glycol ?
Cats
Which are the phases of ethylene-glycol poisoning ?
Phase 1 = nervous systM
Phase 2 = Acidi & <3vasc
Phase 3 = Renal insuff
Phase 4 = Ca oxalate in brain vessels
Spe antidote for ethylene-glycol poisoning ? If yes, which one ?
No - 20% ethanol (hepatotoxic, respi depression & asphyxia) OR Fomepizole
Which is the other name of Paracetamol ?
Acetaminophen
Which is the most susceptible spe to paracetamol ?
Cats
Main CS of paracetamol poisoning :
Vomiting, lethargy, metHbemia, hematuria, respi edema, hepatotoxicity
Spe antidote for paracetamol poisoning ? If yes, which one ?
Sulphydryl donor = acetylcystein, methionine, Na-sulphate, vit C, methylene Bl, cimetidine, ranitidine
Which spe is more sensitive to NSAID’s poisoning ?
Cats
NSAID’s metabo :
Glucoronic acid / glycine
Main NSAID’s effect :
COX inhibitors
-> stomach ulcers & perfo, bloody vomit, melena & kidney damage
Spe antidote for NSAID’s poisoning ? If yes, which one ?
No, antacids, acid secretion inhibitors (H2 antago, proton pump inhibitors & PGE analogues) + coating ag (sucralfate ) & alkalizing urine (NaHCO3)
10kg D can die w/ __________ milk chocolate or ________ dark choclate
300g / 50g
Which are the toxic subst in xanthine poisoning ?
Caffeine & teobromine
Main CS of xanthine poisoning :
CNS & kidneys damage
