Ethosuximide Flashcards
0
Q
Uses of Ethosuximide:
A
Primarily absence/petit mal seizures
DRUG OF CHOICE FOR KIDS
1
Q
Mechanism of action for Ethosuximide:
A
Blocks type t voltage dependent Ca channels channel, resulting in a greater threshold required for action potential propagation
2
Q
Side effects of Ethosuximide:
A
GI: Anorexia, weight loss, gastric upset, cramps, epigastric and adominal pain, diarrhea, vomiting, nausea
Increased risk of congenital malformations when used with phenobarbital (Level 2)
3
Q
Pharmacokinetics
A
Orally. Absorption complete in GI.
Peak levels within 3-7 hrs.
Excreted in the urine (20% unchanged drug excreted in feces)
