Anxiolytic-Sedative-Hypnotics Flashcards
Short-intermediate acting drug that depends on rate of metabolism
Secobarbital
Ultra-short acting, lipid soluble barbiturate
thiopental
The longest acting barbiturate that is either excreted wholly or partially unchanged
Phenobarbital
Should you give barbiturates for pain?
No. In small doses will cause hyperalgesia
What problem arises with habitual barbiturate use?
Tolerance develops more rapidly to its effects on mood and sedation than lethal effect
What do barbiturates act on to cause sleepiness?
GABA receptors
Toxic doses of barbiturates effect which organs?
lungs and heart (become depressed)
How should barbiturates NOT be administered?
Intramuscular
How can phenobarbital overdose be treated and why?
Sodium bicarbonate intravenously to elevate urinary pH
What types of enzymes are elevated by barbiturate use?
hepatic enzymes
Drug class that induces anterograde amnesia but does not administer true anesthetic depth
Benzodiazepines
What enzyme causes the sleepiness for benzo’s?
GABA receptor
How are benzodiazepines toxic to the body?
They… aren’t really. Very little effect on any system outside the CNS
Z class non-Benzodiazapines affect specifically what receptor?
GABAa
