Erythropoeitin

Question 1

how can you reduce the risk of pure red cell aplasia when giving erythropoeisis stimulating agent (ESA’s) ?

Answer 1

use darbopoeitin

Question 2

side effects of erythropoietin ?

Answer 2

irone deficiency
pure red cell aplasia
urticaria, rash
bone ache
flu like symptom
accelerated hypertension that can lead to encephalopathy and seizures
raised PVC increases risk of thrombosis e.g. fistula

Question 3

reasons why patients may fail to respond to erythropeotin ?

Answer 3

iron deficiency 
aluminium toxicity 
concurrent infection/inflammation 
inadequate dose 
hyperparathyroid bone disease