Erythrocyte Series Flashcards
What Progenitor cell are erythrocytes derived from?
Megakaryocyte- Erythrocyte Progenitor
What is the major function of RBCs?
Carry oxygen via having hemoglobin.
Where is erythropoietin made?
Kidney
What is the stimulus for EPO production?
Low oxygen levels
What is the mode of action of EPO.
Acts on earliest committed cell to the erythrocyte series, the Megakaryocyte- Erythrocyte Progenitor.
What is the first Identifiable cell on the erythrocyte series?
Pronormoblast (Rubriblast)
What are names of the six stages of erythrocyte maturation? What is the nucleus/chromatin and cytoplasmic characteristics of each?
- Pronormoblast (Rubriblast) N: Round, Fine C: Navy Blue
- Basophilic Normoblast (Prorubricyte) N: Round, Slightly Condensed C: Navy Blue
- Polychromatic Normoblast (Rubricyte) N: Round, Quite Condensed C: Gray Blue
- Orthochromatic Nortmoblast (Metarubicyte) N: Round, Fully Condensed (Pyknotic) C: Blue to Salmon
- Reticulocyte -Retic N: Absent C: Blue to Salmon
- Erythrocyte -Mature RBC N: Absent C: Salmon
What stage does hemoglobin synthesis begin?
Basophilic Normoblast (Prorubricte)
When is hemoglobin detected by light microscopy?
Polychromatic Normoblast (Rubricyte)
How long does a RBC stay in BM prior to release? (Under normal circumstances)
2 Days (If released early, called stress or shift Retic)
How long does a RBC continue to mature in blood after it is released? (Under normal circumstances)
1 Day (It is becoming fully hemoglobinized)
What is the normal RBC size and lifespan?
6-8 microns
120 plus or minus 10 days
What is the reason for senesence?
No neuclus to make new enzymes (old break down), loss of shape (disc to sphere), too big to fit through spleen cords and caught by spell, phagocytosis by RES cells. This gets rid of old RBCs
