Errors In Cell Cyle Control Flashcards
1
Q
What do mitotic spindle fibres ensure?
A
Accuracy of chromosomes segregation
2
Q
What do centrosomes do?
A
Organise microtubules
Always 2
3
Q
What is aneuploidy?
A
Wrong number of chromosomes
4
Q
What does mitosis errors promote?
A
Numerical chromomes instability and tumour heterogenity which leads to plasticity of cancer
5
Q
What happens is there are amplified centrosomes?
A
Leads to multipolar spindles which promote numerical chromosomal instability
Cancer cells usually possess amplified centrosomes
6
Q
What can cancer cells do to centrosomes so they do not die?
A
Cluster them
Drugs can be produced to stop this
