Equine.GI. PLE, chronic diarrhea, disorders of peritoneum,EPE Flashcards

1
Q

causative agent of equine proliferative enteropathy

A

Lawsonia intracellularis

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2
Q

diagnosis of EPE is dependent on:

A

hypoproteinemia from hypoalbuminemia
thickening of segments of SI wall on abdom U/S
positive serologic findings
molecular detection of L intracellularis in feces

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3
Q

on pig farms, what are important reservoirs of L. intracellularis?

A

mice and rats

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4
Q

L. intracellularis in pathogenesis of EPE

A

invasion of proliferating crypt cells in ileum causing excessive mitotic division and sever hyperplasia–> leads to limited brush boarder development, decreased absorptive capacity = weight loss and hypoproteinemia

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5
Q

What is a ddx in EPE for lawsonia intracellularis?

A

R. equi– can also cause ulceration in areas of Peyers patches throughout SI, cecum and colon

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6
Q

Why is it important to perform molecular & serologic diagnostic testing b/c

A
  • high specificity
    -variable sensitivity
    – dep on situtation
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7
Q

negative serologic results can be expected in what stage of disease with Lawsonia intracellularis

A

** in early stage of disease

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8
Q

In what are of the Small intestine are lesions of L. intracellularis?

A

distal jejunum and ileum
** although diffuse thickening of Si may occur

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9
Q

What stain is used to visualize L. intracellularis in sections of S.I.?

A

Silver staining with Warthin-Starry stain
– elongated, curved bacilli in apical zone of crypt epithelial cells

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10
Q

What is the survival rate for L. intracellularis in foals?

A

93% of treated foals survive the disease

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11
Q

Extrapulmonary R. equi disorders of Gastrointestinal system

A

enterocolitis
typhlitis
intraabdominal abscesses
abdominal lymphadenitis
septic peritonitis

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12
Q

the ability for R. equi to cause disease is based on the presence of:

A

virulence factors
virulence associated protein A

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13
Q

What is the most common small intestinal lesion in R. equi GI disease?

A

multifocal ulcerative enteritis in the area of the Peyer patches of the ileum

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14
Q

What are complications of R. equi enteritis?

A

septic peritonitis
intestinal adhesions

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15
Q

What are frequent cause of severely pruritic cutaneous granulomas in horses along the Gulf coast and southern United States?

A

Pythium spp: conidiobolus and Basidiobolus pp

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16
Q

Pythium suspected pathophysiology

A

transmitted via contact with contaminated water
–> organisms penetrate intestinal mucosa through existing lesion
( can penetrate normal mucosa)

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17
Q

Gross examination of pythium lesions

A

caseous with discrete yellow foci (“kunkers”)
intestinal wall is thickened b/c pyogranulomatous inflammation

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18
Q

Microscopic exam of pythium lesions

A

diffuse, mixed inflammatory infiltrate
granulation tissue
–> submucosa, tunica muscularis & mesenteric attachemnts

19
Q

Diagnosis of Pythium lesions

A

culture– difficult
indirect immunoperoxidase technique– stain for Puthium positive hyphae (some labs)

20
Q

What can be used in the treatment of pythium?

A

antifungals– ineffective
organic iodides
vaccine– can shrink cutaneous lesions

21
Q

Examples of inflammatory bowel diseases?

A

granulomatous enteritis
multisystemic eosinophilic epitheliotropic enterocolitis
eosinophilic enterocolitis
lymphocytic-plasmocytic enteritis
basophilic enterocolitis

22
Q

Idiopathic focal eosinophilic enteritis (IFEE) involves

A

focal areas of eosinophilic inflammatory infiltrates w/in the small intestine

23
Q

Idiopathic focal eosinophilic enteritis lesions

A

intramural masses or circumferential mural bands
– eosinophils w/ or w/o lymphs infiltrating all layers of intestine with varying degrees of fibrosis

24
Q

Are hypoproteinemia and malabsorption are characteristic of idiopathic focal eosinophilic enteritis? True/False

A

False

25
Q

Some Treatments of IBD

A

corticosteroids
anthelmintics
surgical resection

26
Q

What is the most common form of neoplasia of the GIT in horses?

A

alimentary lymphoma
** usu msall intestine

27
Q

Other neoplasms affecting the sm intestine are unusual but typically include

A

adenocarcinoma
leiomyosarcoma
neurofibroma

28
Q

Paraneoplastic syndromes of horses may be the first C/S seen, such as

A

pemphigus
hypoglycemia
hypercalcemia
erythrocytosis
neuropathies

29
Q

Small intestinal fibrosis suggested pathogenesis

A

–clusters of cases missouri & colorado
-unknown pathophysiologic origin of fibosis
– ingestion of toxins: COnvolvulus arvensis or common bind week
– inhibitors of 11 beta-hydroxysteroid dehydrogenase
– compounds of mineralocorticoid activity

30
Q

lymphangiectasia definition

A

dilation of the lymphatic channels of small & large intestine
**usu abscess or neoplasia

31
Q

reports of chyloabdomen result from

A

congenital lymphatic defect in neonatal foals
intraabdominal abscess in a foal
abdominal adhesions in a mini horse

32
Q

Ulcerative duodenitis lesions primary occur where?

A

duodenum

33
Q

The ulcerative duodenitis disorder pathogenesis is considered:

A

peptic disase– damage ot duodenal mucosa results from excessive exposure to HCL and pepsin

34
Q

The origin of ulcerative duodenitis in foals is usually caused by

A

multifactorial:
- breakdown of duodenal mucosal defenses
- interaction of GI peptides
- possible pathogenic agents

35
Q

Complications of ulcerative duodenitis include:

A

duodenal perforation with peritonitis or adhesions
duodenal stricture with complete or partial obstruction
ascending cholangitis & hepatitis
ascending pancreatitis

36
Q

ulcerative duodenitis peritoneal fluid analysis

A

Signs of inflammation
infection
hemorrhage
com of dep on severity of dz

37
Q

treatment of objectives of ulcerative duodenitis

A

decreased duodenal inflammation
treat secondary gastric & esophageal ulceration
promote gastric emptying
treat related problems such as peritonitis

38
Q

Medications described in the treatment of ulcerative Duodenitis?

A

H2 antagonists (cimetidine, ranitidine)
proton pump inhibitors (pantoprazole, omeprazole)
bethanechol
misoprostol
sucralfate
parenteral administration

39
Q

DPJ/anterior enteritis lesions

A

serositis: bright red to dk red petechial & ecchymotic hemorrhages on serosal surfaces

40
Q

DPJ causes increases in volume of duodenogastric reflux by

A

50 to 100 ml/min

41
Q

In anterior enteritis, what is the mechanisms of intestinal fluid secretion

A

passive transmucosal exudationsconary to mucosal & submucosal inflammation & characterized by protein rich fluid secretion
active fluid secretion– caused by INC cyclic nucleotides & characterized by fluid with high elyte content & low protien content

42
Q

What is the most common etx agent that causes anterior enteritis?

A

Clostridium difficile

others include: C. perf, salmonella, etc.

43
Q

What are the criteria used to discriminate between DPJ & obstructive lesions

A

degree of pain after reflux
presence of fever
changes in hematologic parameters & abdominal fluid