Equine.GI. PLE, chronic diarrhea, disorders of peritoneum,EPE Flashcards
causative agent of equine proliferative enteropathy
Lawsonia intracellularis
diagnosis of EPE is dependent on:
hypoproteinemia from hypoalbuminemia
thickening of segments of SI wall on abdom U/S
positive serologic findings
molecular detection of L intracellularis in feces
on pig farms, what are important reservoirs of L. intracellularis?
mice and rats
L. intracellularis in pathogenesis of EPE
invasion of proliferating crypt cells in ileum causing excessive mitotic division and sever hyperplasia–> leads to limited brush boarder development, decreased absorptive capacity = weight loss and hypoproteinemia
What is a ddx in EPE for lawsonia intracellularis?
R. equi– can also cause ulceration in areas of Peyers patches throughout SI, cecum and colon
Why is it important to perform molecular & serologic diagnostic testing b/c
- high specificity
-variable sensitivity
– dep on situtation
negative serologic results can be expected in what stage of disease with Lawsonia intracellularis
** in early stage of disease
In what are of the Small intestine are lesions of L. intracellularis?
distal jejunum and ileum
** although diffuse thickening of Si may occur
What stain is used to visualize L. intracellularis in sections of S.I.?
Silver staining with Warthin-Starry stain
– elongated, curved bacilli in apical zone of crypt epithelial cells
What is the survival rate for L. intracellularis in foals?
93% of treated foals survive the disease
Extrapulmonary R. equi disorders of Gastrointestinal system
enterocolitis
typhlitis
intraabdominal abscesses
abdominal lymphadenitis
septic peritonitis
the ability for R. equi to cause disease is based on the presence of:
virulence factors
virulence associated protein A
What is the most common small intestinal lesion in R. equi GI disease?
multifocal ulcerative enteritis in the area of the Peyer patches of the ileum
What are complications of R. equi enteritis?
septic peritonitis
intestinal adhesions
What are frequent cause of severely pruritic cutaneous granulomas in horses along the Gulf coast and southern United States?
Pythium spp: conidiobolus and Basidiobolus pp
Pythium suspected pathophysiology
transmitted via contact with contaminated water
–> organisms penetrate intestinal mucosa through existing lesion
( can penetrate normal mucosa)
Gross examination of pythium lesions
caseous with discrete yellow foci (“kunkers”)
intestinal wall is thickened b/c pyogranulomatous inflammation