Epithelium Flashcards

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1
Q

What are the 3 main characteristics of epithelium cells?

A
  1. closely adhere to each other
  2. structural and functional polarity
  3. selective barrier
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2
Q

Where is simple squamous epithelium found?

A

endothelium (lines blood vessels)
mesothelium (lines body cavities)
alveoli in lungs

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3
Q

Where is simple cuboidal epithelium found?

A

ovary
kidney tubules
small ducts of glands

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4
Q

Where is simple columnar epithelium found?

A

GI

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5
Q

Where is transitional epithelium found?

A

urinary tract and renal system

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6
Q

Where is pseudostratified ciliated columnar epithelium found?

A

trachea and efferent ductules

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7
Q

What are the 5 main epithelial functions?

A

secretion, absorption, transport, protection, and receptor function

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8
Q

epithelia involved with absorption or secretion are usually what type?

A

simple or pseudostratified

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9
Q

Simple squamous epithelium have a high rate of what?

A

transport

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10
Q

stratification of epithelium usually does what to the permeability?

A

makes it impermeable

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11
Q

Where is the apical domain of the cell?

A

directed toward the exterior surface

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12
Q

Where is the lateral domain?

A

communicates with adjacent cells

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13
Q

Where is the basal domain?

A

rests on the basal lamina

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14
Q

what are stereocilia?

A

really long immotile microvilli

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15
Q

What is the anatomy of a microvilli?

A

contains actin filaments that are anchored at the top by a villin and at the bottom by the terminal web (also actin); Myosin 1 binds the actin to the PM of the microvilli

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16
Q

What is the anatomy of a stereocilia?

A

long actin filaments crosslinked with fimbrin; Their PM is associated with erzin; they have a stem portion that contains alpha-actinin (hair cells lack both erzin and alpha-actinin)

17
Q

What is the anatomy of a cilia

A

organized core of microtubules in a 9 +2 pattern; arms contain ciliary dynein for motor that uses ATP

18
Q

What is the zonula adherens?

A

encircles the cell and allows adhesion of one cell to another

19
Q

What is the zonula occludens?

A

forms a band or seal that completely encircles the cell and prevents flow of material

20
Q

What is the unit of a gap junction?

A

6 connexins make up a connexon

21
Q

What can cause congenital deafness?

A

mutation in CX-26 gap junctions

22
Q

what is a hemidesmosome?

A

found at the contact zone of epithelial cells and the basal lamina and is 1/2 of a desmosome

23
Q

What is bullous pemphigoid?

A

disease where Ab is directed toward protein in hemidesmosomes; triggers mast cells to release eosinophil chemotactic factor (ECF) that attracts eosinophils which break down the hemidesmosome and your skin falls off