Epilepsy Flashcards

1
Q

What is epilepsy?

A

Epilepsy is a neurological condition that affects the central nervous system, resulting in recurrent spontaneous seizures. It is caused by various etiologies and can be triggered by electrical, chemical, or mechanical stimulation.

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2
Q

How common is epilepsy?

A

Epilepsy is one of the most common CNS disorders, affecting about one in a hundred North Americans.

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3
Q

Why is it important for a massage therapist to understand epilepsy?

A

Carelessly applied manual techniques and hydro applications can destabilize control mechanisms in the brain and precipitate seizures. However, massage therapy can also be beneficial by providing relaxation, pain reduction, and injury rehabilitation.

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4
Q

What role does massage therapy play in managing epilepsy?

A

Massage therapy can help provide relaxation, reduce pain and physical stress, and assist in rehabilitation of injuries. However, certain elements of massage therapy can trigger seizures for some patients, so care must be taken to minimize such occurrences.

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5
Q

What are the key considerations for a massage therapist when treating an epileptic patient?

A

The therapist should:

• Obtain necessary case history information
• Determine when not to treat
• Adapt the treatment and environment
• Adjust the treatment plan to account for medications
• Respond appropriately if a seizure occurs

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6
Q

What is the definition of epilepsy?

A

Epilepsy is best defined as a neurological condition that affects the central nervous system, leading to recurrent spontaneous seizures, and is caused by various etiologies.

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7
Q

Can every brain be induced to have a seizure?

A

Yes, virtually every brain can be induced to seizure with sufficient electrical, chemical, or mechanical stimulation.

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8
Q

What percentage of the population will experience a seizure at some point in their life?

A

Seven to ten percent of the population will have a seizure at some point in their lifetime.

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9
Q

What are some situations where seizures can occur without the person being considered epileptic?

A

Seizures can occur due to high fever, drug and hormone reactions, intense sleep or nutritional deprivation, and electroshock therapy.

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10
Q

How is epilepsy diagnosed?

A

Epilepsy is diagnosed if a person has two unprovoked seizures or one unprovoked seizure with a high risk of more, such as within damaged, diseased, or vulnerable brain tissue, or in response to stimuli that wouldn’t cause seizures in a non-epileptic brain.

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11
Q

What is a seizure?

A

A seizure is a sudden onset, self-limiting episode of physical and/or psychological dysfunction caused by an abnormal burst of firing in the CNS. Symptoms are sudden and transient and can include motor, sensory, autonomic, and/or psychic phenomena. These indicate which part of the brain has been activated and often occur in a stereotyped pattern.

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12
Q

Where can the abnormal impulse that causes a seizure arise from?

A

The abnormal impulse can arise from anywhere within the cerebral cortex or deeper brain centers. It may remain localized or spread extensively throughout the brain.

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13
Q

Why are seizures self-limiting?

A

Seizures are self-limiting due to intrinsic inhibitory mechanisms within the CNS and because metabolic wastes accumulate, altering conditions for neuronal firing.

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14
Q

What is the term “ictus” and how is it used?

A

Ictus refers to seizure activity in the brain, and “ictal” is the adjective form used in medical literature related to epilepsy.

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15
Q

What is an irritable or epileptogenic focus?

A

An irritable or epileptogenic focus is a specific area in the brain, which may contain conditions like gliosis, an aneurysm, abnormal chemistry, or a tumor. This area causes spontaneous depolarization or acts as an irritant to nearby neurons, triggering abnormal firing and leading to a seizure.

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16
Q

Are irritable foci always present in epilepsy?

A

No, the presence of irritable foci is common but not always present in epilepsy. Some forms of epilepsy involve generalized abnormal firing from the outset.

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17
Q

What is an aura in the context of epilepsy?

A

An aura is a sensory hallucination experienced by some people with epilepsy before a seizure. It is considered a focal onset aware seizure (FAS), sometimes called a “warning.” Auras can precede other types of seizures.

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18
Q

What are some common symptoms of an aura?

A

Common aura symptoms include:

• Visual: Flashing lights, blurred vision, seeing things that aren’t there.
• Smell: Unpleasant smells like rotten eggs.
• Taste: Odd tastes like metal or bitterness.
• Sounds: Odd noises such as ringing or buzzing.
• Feelings: Emotions like sadness, joy, panic, or fear, as well as nausea or lightheadedness.
• Deja vu: An intense feeling of having experienced something before.
• Body: Stiffness, twitching, numbness, tingling, or changes in the sensation of body parts.

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19
Q

What is a trigger in the context of epilepsy?

A

A trigger is a stimulus, usually sensory, that produces activity in the abnormal brain area, pushing the neuronal tissue beyond its threshold and potentially leading to a seizure.

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20
Q

What are some common seizure triggers?

A

Common seizure triggers include:

• Specific time of day or night
• Sleep deprivation or disrupted sleep
• Illness (with or without fever)
• Flashing bright lights or patterns
• Alcohol (including heavy use or withdrawal)
• Drug use (e.g., cocaine, ecstasy)
• Stress
• Hormonal changes (e.g., menstrual cycle)
• Poor nutrition, dehydration, and low blood sugar
• Specific foods, excess caffeine, or products that aggravate seizures
• Missed medications
• Sensory stimuli like reading or listening to music
• Firing from muscle and joint receptors

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21
Q

What causes epilepsy?

A

Epilepsy can be caused by anything that damages, deranges, or disturbs neuronal function in the brain, leading to a lack of balance between excitatory and inhibitory influences on neurons, disturbing synchronous depolarization patterns.

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22
Q

How do excitatory and inhibitory influences contribute to epilepsy?

A

While most seizures result from excitation predominance (e.g., tonic-clonic seizure), inhibition predominance also occurs (e.g., absence seizures).

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23
Q

What populations have the greatest prevalence of epilepsy?

A

Epilepsy prevalence is greatest in the younger and older populations. Seizures begin before 18 in more than 75% of cases.

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24
Q

What happens to epilepsy incidence in adulthood?

A

Epilepsy often subsides in early to middle adulthood, with a relatively smaller incidence in the 30-50 age group. However, there is an increase in new diagnoses after age 50, often related to strokes, diabetes, and other organ pathologies.

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25
Q

How do heart failure and cardiac dysrhythmia relate to epilepsy?

A

Heart failure and cardiac dysrhythmia are associated with seizures as they can adversely affect blood/nutrient supply to the brain and clearance of toxic elements.

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26
Q

What impact can drugs have on epilepsy development?

A

Certain drugs that lower the seizure threshold can contribute to the development of epilepsy, especially in older age groups.

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27
Q

What are the common known causes of epilepsy?

A

Known causes of epilepsy include infections, autoimmune epilepsy, genetic factors, metabolic disorders, and structural brain abnormalities.

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28
Q

What infections can lead to epilepsy?

A

Infections that can lead to epilepsy include:

• Cerebral malaria
• TORCH infections (toxoplasmosis, rubella, cytomegalovirus, herpes simplex)
• Bacterial meningitis
• Viral encephalitis
• Tuberculosis
• HIV

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29
Q

How is autoimmune epilepsy associated with other conditions?

A

Autoimmune epilepsy is more likely in people with a history of autoimmune diseases, cancer, or first-degree relatives with autoimmune diseases.

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30
Q

How does genetics contribute to epilepsy?

A

Genetic epilepsy occurs when individuals inherit abnormal genes that increase the risk of seizures, especially in idiopathic generalized epilepsy cases.

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31
Q

What metabolic disorders are linked to epilepsy?

A

Metabolic disorders, such as Type 1 Diabetes, are associated with a higher likelihood of developing epilepsy, with Type 1 Diabetics being nearly three times more likely.

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32
Q

What structural brain causes are associated with epilepsy?

A

Structural causes include:

  1. Head trauma
  2. Stroke-related vascular injury
  3. Brain tumors
  4. Brain degenerative diseases (e.g., Alzheimer’s)
  5. Perinatal brain injury and malformations
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33
Q

What disorders are strongly associated with epilepsy?

A

Conditions strongly associated with epilepsy include cerebral palsy (30-50% of children with CP have epilepsy), intellectual disability, autism, learning disabilities (especially dyslexia), and psychiatric disorders (e.g., psychosis, depression, hyperactivity).

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34
Q

What histological changes occur during an epileptic seizure?

A

The abnormal firing surge in seizures reflects changes in synchronization and intensity of influences on neurons. This results from a heightened degree of facilitation and shifts in the balance of excitatory and inhibitory neurochemistry.

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35
Q

What role do sodium and potassium play in neuronal firing?

A

Neurons fire when the balance of resting potential is altered, causing sodium to flow into the cell and potassium to flow out. This activity leads to depolarization, which is necessary for conduction toward a synapse.

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36
Q

What role does calcium play in neuronal function?

A

Calcium outside the cell helps maintain membrane stability and a healthy depolarization threshold, contributing to normal neuronal firing.

37
Q

How does GABA affect epilepsy?

A

GABA-mediated processes are decreased in epilepsy. This leads to prolonged activation at neuronal synapses, causing hypopolarization and facilitating impulse bursts that initiate seizures.

38
Q

What factors can upset the balance of neuronal membrane activity in epilepsy?

A

Factors include:

  1. Brain toxicity
  2. Altered concentrations of ions
  3. Deficiencies in necessary substances like folic acid, B vitamins, glutamate, and glycine
  4. Damaged blood-brain barrier
  5. Malfunctioning glial cells
  6. Membrane defects or myelination issues
  7. Damage to cerebrospinal fluid regulation systems
  8. Extremes in blood pressure or CSF pressure
  9. Norepinephrine depletion
  10. Excess endorphins and enkephalins
39
Q

How is epilepsy diagnosed?

A

Epilepsy is diagnosed based on clinical history, neurological exams, blood tests, and confirmation of neuronal firing abnormalities using EEG. Other scans like CT, MRI, and PET may also be used.

40
Q

What conditions are often misdiagnosed as epilepsy?

A

Conditions misdiagnosed as epilepsy include:

  1. Psychogenic non-epileptic attacks
  2. Syncope
  3. Hypoglycemia
  4. Panic attacks
  5. Paroxysmal movement disorders
  6. Paroxysmal sleep disorders
  7. TIAs
  8. Migraines
  9. Transient global amnesia (TGA)
41
Q

What is the success rate of drug therapy for epilepsy when using the first medication?

A

47% of people become seizure-free with the first anti-seizure medication.

42
Q

What happens when a second anti-seizure drug is tried after the first one fails?

A

An additional 14% of people become seizure-free with the second medication.

43
Q

What is the effect of trying more than two anti-seizure drugs?

A

The response to medications decreases markedly when more than two drugs are tried.

44
Q

What are the drawbacks of drug therapy for epilepsy?

A

Many anti-seizure medications can have psychogenic effects, especially with long-term use, and this can be particularly problematic when treatment begins in childhood.

45
Q

How does the prescription of epilepsy medication vary?

A

The prescription varies depending on the seizure type and the person’s individual tolerance. Doctors must balance controlling seizures with minimizing negative side effects.

46
Q

How many drugs are in the anti-epilepsy group?

A

There are over 30 drugs in the anti-epilepsy group.

47
Q

What is required to assess the potential impact of anti-seizure medications?

A

Research into a patient’s particular medications is needed to assess the potential side effects.

48
Q

What is the typical drug therapy pattern for epilepsy?

A

The typical pattern involves one or more anti-seizure medications and a tranquilizing drug, although the anti-convulsant can sometimes be given alone.

49
Q

What is neuromodulation in the context of epilepsy treatment?

A

Neuromodulation involves using a device to send small electric currents to the nervous system and is an option for patients with focal epilepsy where medications do not work.

50
Q

Name three approaches to neuromodulation for epilepsy.

A

Vagus nerve stimulation (VNS Therapy®), responsive neurostimulation (RNS® Therapy), and deep brain stimulation.

51
Q

When might surgery be considered for epilepsy treatment?

A

Surgery may be considered when seizures persist despite medications, diet (like ketogenic), devices, or other therapies.

52
Q

What is the goal of most surgical interventions for epilepsy?

A

The goal is to remove epileptogenic foci or other parts of the brain associated with seizures, such as those in the frontal, temporal, parietal, or occipital lobes.

53
Q

What are less invasive surgical options for treating epilepsy?

A

Laser interstitial thermal therapy (LITT) and stereotactic radiosurgery are less invasive options that do not require craniotomy.

54
Q

Why is brain surgery considered less desirable than drug therapy for epilepsy?

A

Brain surgery carries risks, and while it can be curative in some cases, it is less desirable compared to the lower-risk drug therapies.

55
Q

What is phenobarbital used for?

A

Phenobarbital is used as an anti-seizure medication.

56
Q

What are the three major groups of seizures?

A

Generalized onset, focal onset, and unknown onset seizures.

57
Q

What is a tonic-clonic seizure?

A

A tonic-clonic seizure (formerly Grand Mal) affects both sides of the brain and involves two phases: tonus (rigidity) and clonus (spasmodic contraction/relaxation).

58
Q

What occurs during the tonic phase of a tonic-clonic seizure?

A

The entire body becomes rigid, and the person loses consciousness, often falling.

59
Q

What occurs during the clonic phase of a tonic-clonic seizure?

A

The body undergoes spasmodic contractions and relaxations.

60
Q

What are common symptoms during a tonic-clonic seizure?

A

Tongue biting, cheek biting, possible bloody saliva, urinary or fecal incontinence, cyanosis (blue skin) in the face, and post-ictal amnesia (lack of memory immediately before the seizure).

61
Q

How long does a typical tonic-clonic seizure last?

A

A typical tonic-clonic seizure lasts 1-3 minutes.

62
Q

What should be done if a tonic-clonic seizure lasts longer than 5 minutes?

A

Immediate emergency medical help should be sought if a tonic-clonic seizure lasts longer than 5 minutes.

63
Q

What should be done if a tonic-clonic seizure lasts longer than 5 minutes?

A

Immediate emergency medical help should be sought if a tonic-clonic seizure lasts longer than 5 minutes.

64
Q

What are the post-ictal effects after a tonic-clonic seizure?

A

After a seizure, the person may feel sleepy, confused, irritable, or depressed for up to 48 hours.

65
Q

Why are tonic-clonic seizures considered dangerous?

A

Tonic-clonic seizures are among the most common and dangerous types, subject to frequent complications.

66
Q

What is the difference between generalized onset and focal onset seizures?

A

Generalized onset seizures affect both sides of the brain simultaneously, while focal onset seizures begin in one area of the brain and may or may not spread.

67
Q

What is the most common outcome when individuals first start anti-seizure medications?

A

Only 47% of people become seizure-free with the first medication.

68
Q

How does the effectiveness of anti-seizure medications change after trying multiple drugs?

A

When a second drug is tried, an additional 14% of people become seizure-free, but the response to medications decreases significantly when more than two drugs are tried.

69
Q

What are some long-term side effects of epilepsy medications?

A

Long-term use of epilepsy medications can lead to psychogenic effects, especially when drug therapy begins in childhood.

70
Q

How are anti-seizure medications prescribed?

A

The prescription depends on the seizure type and the individual’s tolerance. The doctor must balance controlling seizures with minimizing the negative effects of the medications.

71
Q

What are some common types of anti-seizure medications?

A

There are over 30 drugs in the anti-epilepsy group. Some common treatments also include tranquilizing drugs, sometimes in combination with anti-seizure medications.

72
Q

What is neuromodulation for epilepsy?

A

Neuromodulation involves using devices to send small electrical currents to the nervous system, and it’s used for patients with focal epilepsy when medications do not work.

73
Q

What are the three approaches to neuromodulation for epilepsy?

A

Vagus nerve stimulation (VNS Therapy®), responsive neurostimulation (RNS® Therapy), and deep brain stimulation.

74
Q

When is surgery considered for treating epilepsy?

A

Surgery may be an option when seizures persist after trying medications, diet, devices, or other therapies.

75
Q

What are common surgical interventions for epilepsy?

A

The aim is to remove epileptogenic foci or other brain areas involved in seizures, often in the frontal, temporal, parietal, or occipital lobes.

76
Q

What are less invasive options for treating seizures surgically?

A

Laser interstitial thermal therapy (LITT) and stereotactic radiosurgery, which do not require craniotomy, are less invasive options for more defined seizure foci.

77
Q

What are the risks of brain surgery for epilepsy treatment?

A

Brain surgery carries significant risks, making it less preferred than drug therapy, although in some cases, complete cures can be achieved.

78
Q

What are the symptoms of a tonic-clonic seizure (formerly known as grand mal)?

A

The seizure starts with rigidity (tonus), followed by spasmodic contractions (clonus), loss of consciousness, possible tongue biting, urinary/fecal incontinence, and confusion or irritability post-seizure.

79
Q

What should be done if a tonic-clonic seizure lasts longer than 5 minutes?

A

Immediate emergency medical help is required if a tonic-clonic seizure lasts longer than 5 minutes.

80
Q

What are absence seizures (formerly known as petit mal)?

A

Absence seizures involve a sudden cessation of activity, often appearing as staring or having a blank look. They last less than 10 seconds, though atypical ones can last longer, and are common in children.

81
Q

What are the characteristics of atonic seizures (drop attacks)?

A

The person may lose muscle tone, causing them to fall, drop things, or nod their head. These seizures typically last less than 15 seconds and may result in injury.

82
Q

What are myoclonic seizures?

A

Myoclonic seizures are brief, jerky contractions that affect both sides of the body simultaneously, often occurring shortly after waking up.

83
Q

What is a focal onset impaired awareness seizure (formerly complex partial)?

A

This seizure involves impaired awareness, unusual posturing, and may include automatisms like lip-smacking or walking without purpose. It typically lasts 30 seconds to 2 minutes.

84
Q

What are some common complications of seizures?

A

Seizure complications can include injuries, Todd’s Paralysis, status epilepticus, cardiac arrest, and respiratory arrest.

85
Q

What is Todd’s Paralysis (postictal paralysis)?

A

Todd’s Paralysis is a brief period of temporary paralysis following a seizure, most commonly after clonic seizures, which can last from half an hour to 36 hours.

86
Q

What is status epilepticus?

A

Status epilepticus occurs when a seizure lasts longer than 5 minutes or when seizures occur in rapid succession without recovery between them. It is a medical emergency.

87
Q

What are the common causes of status epilepticus?

A

Non-compliance with medication, alcohol withdrawal, metabolic diseases, tumors, and infarctions are the most common causes of status epilepticus.

88
Q

What long-term complications can arise from frequent seizures?

A

Long-term complications can include intellectual deterioration, learning difficulties, neurotic behaviors, and intensification of epilepsy. Recurrent seizures can also cause brain damage.

89
Q

How do seizures affect the heart?

A

Convulsive seizures can lead to conduction abnormalities in the heart and weaken the heart as a pump, increasing the risk of congestive heart failure (CHF).