CNS: Sensory Review Flashcards

1
Q

What do afferent (sensory) neurons do?

A

Afferent neurons carry information from the body’s tissues via receptors about internal and external environments to the central nervous system (CNS).

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2
Q

How many times more afferent neurons are there compared to efferent neurons in the human body?

A

There are about 20 times more afferent neurons than efferent neurons.

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3
Q

What is the purpose of afferent data in the CNS?

A

The purpose is to inform the CNS about internal and external events so responses can be properly designed and initiated, ensuring good conscious perception as needed.

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4
Q

What is a reflex?

A

A reflex is an automatic efferent reaction triggered by incoming sensory information without the need to reach the brain.

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5
Q

What is the neural pathway called that describes a reflex?

A

The neural pathway is called a reflex arc, consisting of Afferent -> Interneuron -> Efferent.

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6
Q

What happens to afferent information that arrives in the brain processing centers?

A

It receives more complex analysis, allowing for customized, situation-specific responses that can involve emotional and cognitive aspects.

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7
Q

What is sensory input or afferentation?

A

Data that is carried as afferent transmission along the neurons of the sensory system into the CNS for interpretation and response.

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8
Q

How do sensation, sensory experience, and sensory perception differ?

A

• Sensation: The conscious awareness of sensory input.
• Sensory Experience: The subset of afferentation that rises to consciousness and is interpreted.
• Sensory Perception: The individual’s impression or interpretation of sensory input (e.g., olfactory receptors detecting molecules and perceiving them as scent).

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9
Q

What is the difference between nociception and pain perception?

A

• Nociception: The process of detecting tissue stress/damage and conveying this information to the CNS.
• Pain Perception: Occurs when the brain assigns a sensory experience to the nociceptive data, resulting in the conscious experience of pain.

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10
Q

Does the presence of afferentation from tissues guarantee sensation?

A

No, the presence of afferentation does not guarantee sensation, as all sensation is assigned by the brain.

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11
Q

How do olfactory receptors contribute to sensory perception?

A

Olfactory receptors detect ambient molecules and inform the CNS. If this data is selected for experience, the perception of it is referred to as a scent.

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12
Q

What role do nociceptors play in sensory transmission?

A

Nociceptors detect tissue stress/damage and convey this information to the CNS. At this stage, it is called nociception; it is only referred to as pain or pain perception when the person has a sensory experience of it.

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13
Q

What are the specialized receptors in the somatosensory system responsible for?

A

Stimuli are detected in the tissues by receptors that are specialized for specific stimulus types. These receptors are the distal ends of afferent neurons, called First Order Neurons.

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14
Q

What are the specialized receptors in the somatosensory system responsible for?

A

Stimuli are detected in the tissues by receptors that are specialized for specific stimulus types. These receptors are the distal ends of afferent neurons, called First Order Neurons.

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15
Q

What is the function of First Order Neurons in the somatosensory system?

A

First Order Neurons convey the transmission of stimuli to the spinal cord. Their synapses occur either in the dorsal horn of the spinal cord or farther up in the brainstem, with some arriving at the brainstem via cranial nerves.

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16
Q

Who are the secondary or second order (2°) sensory neurons and what is their role?

A

Secondary or second order (2°) sensory neurons carry the afferentation from the First Order Neurons to the thalamus.

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17
Q

What is the role of the thalamus in the somatosensory system?

A

The thalamus acts as a reception/relay station for the brain. Its crucial role in sensation is to convey data, via the tertiary or third order (3°) neurons, to the Somatosensory Cortex and related brain areas for memory, emotion, cognition, and autonomics.

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18
Q

How does the anatomy of the somatosensory system differ from that of special senses and visceral sensation?

A

While the focus is on somatosensation, there are anatomical differences for the special senses and visceral sensation that will arise when relevant in the study of the somatosensory system.

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19
Q

What is a typical First Order (1°) Neuron attached to?

A

A typical First Order Neuron is attached to one or more specific type of receptors embedded in tissue.

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20
Q

What determines if an action potential is initiated in a First Order Neuron?

A

The receptors have stimulus thresholds; if the stimulus is strong enough, an action potential is initiated.

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21
Q

Describe the process of depolarization in First Order Neurons.

A

The resulting depolarization wave travels along the axon toward the cell body, which is located in the dorsal root ganglion.

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22
Q

What is the peripheral branch/process of a First Order Neuron?

A

The axon from the receptor to the cell body is called the peripheral branch/process of the neuron. These branches are located in the peripheral nerve and then the spinal nerve that corresponds with their supply tissue.

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23
Q

How does transmission move into the CNS from a First Order Neuron?

A

From the cell body, the transmission moves quickly into the CNS at the spinal cord’s dorsal horn. The axon that enters the dorsal horn is called the central process of the 1° neuron.

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24
Q

Where is the receptor of each First Order (1°) neuron located?

A

The receptor is located in the tissue it is responsible for sensing and reporting about, generating information about a specific stimulus type occurring in a discrete location, known as its Receptive Field.

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25
Q

How are the peripheral branches of First Order Neurons organized?

A

The peripheral branches are bundled together into fascicles, which are then grouped into a peripheral nerve responsible for that tissue zone.

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26
Q

What is meant by a nerve’s “Supply Tissue”?

A

The identified pattern of sensation responsibility that a nerve has, typically consisting of smaller areas where the nerve exclusively carries afferent neurons and larger zones where it is the primary but not exclusive supplier.

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27
Q

How do peripheral branches of First Order Neurons change upon entering a spinal nerve?

A

Once their peripheral branches enter a spinal nerve, the same neurons are in a different configuration; many peripheral nerves carry a group of neurons that sense the same tissue zone but do not all report to the same spinal cord segment.

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28
Q

What are examples of peripheral nerves that carry neurons sensing the same tissue zone?

A

Various plexuses, including cervical, brachial, lumbar, sacral, etc.

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29
Q

What does a spinal nerve contain?

A

A spinal nerve contains all the neurons whose functions correspond to one spinal cord level.

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30
Q

What is a dermatome?

A

A spinal nerve’s pattern of skin responsibility.

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31
Q

What is a sclerotome?

A

A spinal nerve’s sclerotome includes deeper structures such as bone, periosteum, and joints.

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32
Q

What does the term “Ridcular” refer to?

A

“Ridcular” means “of the root,” referring to the nerve roots from a specific spinal segment.

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33
Q

What does the spinal nerve consist of?

A

The spinal nerve is the combination of the nerve roots from that spinal segment.

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34
Q

What do the illustrations of peripheral and spinal nerve supply tissue patterns depict?

A

The illustrations show the dermatomal patterns for the skin of the whole body, including anterior and posterior views.

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35
Q

How many identified sensory modalities are there in humans?

A

There are at least 17 identified sensory modalities.

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36
Q

What is the term used for senses with receptors distributed throughout various tissue types?

A

General Sense.

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37
Q

What distinguishes Special Senses from General Senses?

A

Special Senses have receptors located in one part of the body with dedicated sense organs, often with specific interpretation areas in the brain (e.g., vision, smell, hearing, taste).

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38
Q

How are senses like touch and equilibrium categorized by experts?

A

They are considered principal sensory categories but do not have distinct receptors; they integrate data from several receptor types.

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39
Q

What is sensory transduction?

A

Sensory transduction is the process by which receptors transform the energy of a stimulus into electrochemical impulses (action potentials) that travel along neurons toward the CNS.

40
Q

What is an Adequate Stimulus in relation to receptors?

A

An Adequate Stimulus is the particular stimulus type to which a receptor is sensitive.

41
Q

What do receptors allow us to do in response to stimuli?

A

Receptors register stimuli and enable us to understand, perceive, and respond to data about what is happening in and around our bodies.

42
Q

How can receptors be classified?

A

Receptors can be classified by their adequate stimulus, morphology, rate of adaptation, and firing threshold.

43
Q

What role do receptors play in sensory experience?

A

Receptors are the sensory end-organs that register stimuli and initiate transmission to the CNS for interpretation.

44
Q

What is the Stimulus Type (Adequate Stimulus) of Mechanoreceptors?

A

Mechanical Forces as Applied to Tissue e.g. pressure, stretch/distortion, tension

45
Q

What is the Stimulus Type (Adequate Stimulus) of THERMORECEPTORS?

A

Temperature (Relative to Tissue Temperature)
heat, cold

46
Q

What is the Stimulus Type (Adequate Stimulus) of Nociceptors?

A

Potential Damage in Tissue; Actual Tissue Damage
Potential Damage From Beyond-Threshold Stimuli,

e.g. extremes of cold/heat (thermal nociceptors), excess pressure or mechanical deformation (mechanical nociceptors) and a range of chemicals including those that can damage tissues and those that are evidence of tissue damage (chemical nociceptors)

47
Q

What is the Stimulus Type (Adequate Stimulus) of Proprioception?

A

Sense of Position located near mobile parts; includes placement, stretch, effects of movement, etc.

48
Q

What is the Stimulus Type (Adequate Stimulus) of Kinaesthetic Receptor?

A

Sense of Movement
often included in term proprioceptor

49
Q

What is the Stimulus Type (Adequate Stimulus) of Baroreceptor?

A

Pressure in Blood Vessel Walls
↑/↓ wall deformation
* Morphology: Sensory receptors fall into three main groupings based on their form

50
Q

What are the three main groupings of sensory receptors based on their morphology?

A
  1. Free Nerve Endings
  2. Encapsulated Receptors
  3. Specialized Cells
51
Q

What are Free Nerve Endings?

A

Free Nerve Endings (also known as bare, naked, or unmyelinated receptors) are common receptors found extensively in the skin (epidermis and dermis) and other structures. They sense nociception, temperature, and hair follicle movement, and typically have several sensing ends per neuron embedded directly in tissues.

52
Q

How do Encapsulated Receptors differ from Free Nerve Endings?

A

Encapsulated Receptors (also known as protected, bulbous, or lamellar receptors) have endings that are “bare” but encapsulated in a structure that tunes them to specific stimuli, lowering their firing threshold. They are often sensitive to stretch and pressure, detecting vibrations from light touch or gradations of deformation/pressure.

53
Q

What type of receptors are used for the special senses?

A

Specialized Cells are complex, distinct cells that synapse with first-order (1°) neurons and are used for the special senses.

54
Q

What is the role of encapsulation in Encapsulated Receptors?

A

The encapsulation acts to attune the receptors to specific stimuli, helping to lower their firing threshold for detecting those stimuli.

55
Q

What is the priority of the sensory system regarding stimuli?

A

The priority of the sensory system is to keep track of new or worrisome stimuli. Identified benign stimuli typically lose signal intensity quickly.

56
Q

What is a tonic receptor?

A

A tonic receptor adapts slowly to a stimulus and continues to produce action potentials for the duration of the stimulus. Examples include nociception, joint capsule stretch, and baroreception. Some tonic receptors are permanently active, such as the 1a sensory neuron in muscle spindles, to convey a background level of firing.

57
Q

What kind of parameters do tonic receptors monitor?

A

Tonic receptors monitor parameters that must be continually evaluated, such as nociception and joint capsule stretch.

58
Q

What is a phasic receptor?

A

A phasic receptor adapts rapidly to a stimulus. It communicates the stimulus initially, but the response diminishes quickly and often stops. It will fire again to signal significant changes in the speed or intensity of the stimulus or when the stimulus stops.

59
Q

Why are phasic receptors important for the body?

A

These receptors allow the body to ignore constant unimportant information. Most exteroreceptors are phasic.

60
Q

Can you give examples of where tonic and phasic receptors are commonly found?

A

Tonic receptors are found in systems requiring continuous monitoring, like muscle spindles. Phasic receptors are commonly found in areas sensing tissue indentation or vibration, allowing adaptation to constant external stimuli.

61
Q

What is meant by the “firing threshold” of a receptor?

A

Firing threshold refers to how sensitive a receptor is to its adequate stimulus, determining the level of stimulus required to activate the receptor.

62
Q

What are low threshold receptors?

A

Low threshold receptors are highly sensitive and are immediately activated by their adequate stimulus. They generally sense innocuous, everyday stimuli and convey information related to routine sensory functions.

63
Q

What are high threshold receptors?

A

High threshold receptors have a higher activation threshold and are used to detect harm or potential harm in their tissues. They are sensitive to chemicals, extremes of temperature, and mechanical stress.

64
Q

What types of stimuli do low threshold receptors typically sense?

A

Low threshold receptors typically sense innocuous, everyday types of stimuli, such as routine touch, temperature, and movement.

65
Q

What types of stimuli do high threshold receptors detect?

A

High threshold receptors detect harmful or potentially harmful stimuli, including extreme temperatures, chemical changes, and mechanical stress.

66
Q

What is the function of afferent neurons?

A

Afferent neurons carry information from the body’s tissues via receptors about the internal and external environments to the CNS. There are about 20 times more afferent neurons than efferent neurons in the body.

67
Q

What is the function of efferent neurons?

A

Efferent neurons transmit directive signals from the CNS to effectors in body tissues.

68
Q

What is the purpose of afferent data?

A

Afferent data informs the CNS about the internal and external environments, ensuring that responses are properly designed and initiated, and supports conscious perception.

69
Q

What is a reflex arc?

A

A reflex arc is a simple reflex pathway: Afferent -> Interneuron -> Efferent. Reflexes trigger automatic efferent reactions without reaching the brain.

70
Q

What is sensory input/afferentation?

A

Sensory input, or afferentation, is the data carried as afferent transmission along neurons of the sensory system into the CNS for interpretation and response.

71
Q

What is sensory experience or perception?

A

Sensory experience or perception is the conscious awareness of sensory input. Most afferentation does not lead to sensory experience as it is filtered out or suppressed.

72
Q

How do receptors function in the somatosensory system?

A

Receptors detect stimuli in tissues and transmit signals to the CNS via first-order neurons. These signals are conveyed to the spinal cord or brainstem.

73
Q

What is the role of first-order neurons?

A

First-order neurons are attached to receptors in tissues. They convey stimulus transmission to the spinal cord, with synapses occurring in the dorsal horn or brainstem.

74
Q

What is the role of second-order and third-order neurons?

A

Second-order neurons carry afferentation to the thalamus, which acts as a relay station. Third-order neurons relay data from the thalamus to the somatosensory cortex and related brain areas (e.g., for memory, emotion, cognition).

75
Q

What is the “supply tissue” of first-order neurons?

A

The “supply tissue” refers to the tissue that a first-order neuron’s receptors are responsible for sensing and reporting about, based on its receptive field. Multiple neurons are bundled into fascicles that form peripheral nerves serving specific tissue zones.

76
Q

What are dermatomes and sclerotomes?

A

A dermatome is a spinal nerve’s skin responsibility pattern, while a sclerotome is a spinal nerve’s responsibility for deeper structures such as bone, periosteum, and joints.

77
Q

What are dermatomes and sclerotomes?

A

A dermatome is a spinal nerve’s skin responsibility pattern, while a sclerotome is a spinal nerve’s responsibility for deeper structures such as bone, periosteum, and joints.

78
Q

What are free nerve endings?

A

Free nerve endings are bare, unmyelinated nerve endings found in the skin and other structures. They are responsible for sensing nociception, temperature, and hair follicle movement.

79
Q

What are encapsulated receptors?

A

Encapsulated receptors are bare nerve endings enclosed in a capsule that attunes them to specific stimuli. They are often sensitive to vibration caused by light touch or stretch.

80
Q

What are specialized receptor cells?

A

Specialized receptor cells are distinct cells that synapse with first-order neurons, primarily used in special senses such as vision and hearing.

81
Q

What is the difference between tonic and phasic receptors?

A

• Tonic receptors: Adapt slowly to stimuli and continue to produce action potentials for the stimulus duration (e.g., nociception, joint stretch).
• Phasic receptors: Adapt quickly to stimuli, firing only in response to changes in stimulus intensity or when the stimulus ends (e.g., touch, vibration).

82
Q

What are low-threshold receptors?

A

Low-threshold receptors are sensitive receptors that are activated immediately by their adequate stimulus. They generally detect everyday innocuous stimuli and convey routine sensory information.

83
Q

What are high-threshold receptors?

A

High-threshold receptors have a higher activation threshold and are used to detect harm or potential harm in tissues. They are sensitive to extremes of temperature, mechanical stress, and chemicals.

84
Q

How does axon diameter and myelination affect conduction speed in first-order neurons?

A

• C-fibers: Smallest, unmyelinated, slowest conduction.
• A-delta fibers: Medium size, lightly myelinated.
• A-beta fibers: Largest, thickly myelinated, fastest conduction.
Larger, more myelinated neurons (e.g., proprioceptors) conduct faster for reflexes and fine motor control, while slower ones (e.g., C-fibers) convey pain or diffuse touch.

85
Q

Question: Where do 1° afferent neurons synapse with 2° neurons?

A

1° afferent neurons synapse with 2° neurons in the spinal cord.

86
Q

What is the primary role of 2° neurons?

A

2° neurons are responsible for conveying afferent data into the brain, mostly to the thalamus. They are organized into tracts where neurons of the same sensation type travel together.

87
Q

How does the convergence of 1° neurons onto 2° neurons affect signal transmission?

A

A large number of 1° neurons converge onto a smaller number of 2° neurons in the spinal cord, meaning incoming signals are consolidated or summarized before being sent to the brain. This creates a “picture” of the sensory situation based on multiple factors such as receptor type, density, and transmission speeds.

88
Q

What factors influence the “picture” communicated by 1° neurons to 2° neurons?

A

Factors include receptor type, density, tissue movement, temperature, tissue risk, proportion of slow/fast adaptors, size of the grouped receptor fields, and the mix of thresholds and transmission speeds.

89
Q

Where is afferent information interpreted in the brain?

A

Afferent information is interpreted in the somatosensory cortex areas on the opposite side of the brain from where the stimulus originated.

90
Q

What is the process of decussation in the context of 2° neurons?

A

Decussation refers to the crossing over of 2° neuron signals to the opposite (contralateral) side of the brain. 2° neurons carry data contralaterally after crossing over in the spinal cord or brainstem.

91
Q

Where do most afferent signals decussate, and where are they transmitted afterward?

A

Most afferent signals travel up the spinal cord ipsilaterally and decussate in the medulla oblongata in the brainstem. After decussation, they are carried to the contralateral thalamus by 3° neurons.

92
Q

How do nociception, temperature, and crude touch information differ in their pathway to the brain?

A

Nociception, temperature, and crude touch information meet their 2° neurons immediately upon entering the spinal cord. These signals cross over (decussate) right away and travel up the contralateral side to the brain.

93
Q

Where are interneurons located in the sensory pathway?

A

Interneurons are situated between the incoming 1° neurons and the cell bodies of the 2° neurons, ready to carry data to the brain.

94
Q

What is a significant exception in the transmission of afferent information by 2° neurons?

A

An exception is afferent information traveling directly to the cerebellum via the spinocerebellar tracts, where the data is never experienced as sensation.

95
Q

Where does the bulk of 2° neuron transmission go for analysis and response?

A

The bulk of 2° neuron transmission heads to the brain, specifically to the thalamus, for analysis and response processes.

96
Q

What is the role of the thalamus in sensory perception?

A

The thalamus is the central receiving area for afferent information and is crucial for sensory perception. It communicates with the somatosensory cortex and other brain association areas.

97
Q

What is the role of 3° neurons in sensory transmission?

A

The third order neurons are the communication channels of the thalamus, transmitting data from the thalamus to the somatosensory cortex and other brain areas involved in sensory perception.