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Y2 Pharmacology > Epilepsy > Flashcards

Epilepsy Flashcards

1
Q

What is the target & effect of lamotrigine?

A

Target: Blocks Na+-gated channels
Effect: reduce Na+ influx and depolarisation of glutamatergic neurones

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2
Q

What is the target & effect of sodium valproate?

A

Target: Blocks GABA-transaminase enzyme
Effect: reduced breakdown of GABA

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3
Q

What is the target & effect of diazepam?

A

Target: benzodiazepine binding site on GABA-A receptor
Effect: increases Cl- influx after GABA binds, causing increased hyperpolarisation

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4
Q

What is the target & effect of levetiracetam?

A

Target: SV2A proteins in excitatory pre-synaptic neurone
Effect: reduced exocytosis of glutamate

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5
Q

What does ‘clonic’ mean?

A

Jerking

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6
Q

What does ‘tonic’ mean?

A

Stiffness

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7
Q

What are the drug interactions between lamotrigine and the combined contraceptive pill?

A

COC reduces lamotrigine levels by affecting enzymes which break down lamotrigine

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8
Q

Why isn’t sodium valproate given as a first-line treatment for women of childbearing age?

A

Causes neural tube defects, decreased IQ, autism

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Y2 Pharmacology (7 decks)

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