Asthma

Question 1

What is the target & effect of salbutamol?

Answer 1

Target: β2 adrenergic receptor agonist
Effect: reduces Ca2+ entry and prevents smooth muscle contraction

Question 2

What is the target & effect of fluticasone?

Answer 2

Target: glucocorticoid receptor
Effect: reduces inflammatory cells and cytokines

Question 3

What is the target & effect of mometasone?

Answer 3

Target: glucocorticoid receptor
Effect: reduces inflammatory cells and cytokines

Question 4

What is the target & effect of budesonide?

Answer 4

Target: glucocorticoid receptor
Effect: reduces inflammatory cells and cytokines

Question 5

What is the target & effect of montelukast?

Answer 5

Target: CysLT1 leukotriene receptor antagonist
Effect: decreased eosinophilia, bronchoconstriction and inflammation

Question 6

What are the 5 mechanisms in which inhaled medication does NOT influence lung function?

Answer 6

1. exhaled
2. ingested
3. cleared by mucociliary clearance
4. absorbed into bloodstream in lungs
5. not inhaled properly

Question 7

Why is montelukast used for NSAID-induced asthma?

Answer 7

NSAIDs are COX inhibitors, so shifts arachidonic acid breakdown pathway to leukotriene side