CKD

Question 1

Target & effect of statins

Answer 1

Target: HMG-CoA reductase competitive inhibitor
Effect: reduced cholesterol synthesis, upregulation of LDL receptors and hepatic uptake

Question 2

Target and effect of aspirin

Answer 2

Target: COX enzyme irreversible inactivator
Effect: reduced production of prostaglandins and TA2, reduces pain and anticoagulates blood

Question 3

Target & effect of trimethoprim

Answer 3

Target: dihydrofolate reductase, direct competitor
Effect: antibiotic - decreased synthesis of DNA and proteins

Question 4

Which drug affects creatinine clearance and how does this affect GFR calculation?

Answer 4

Trimethoprim - inhibits active secretion of creatinine
Therefore invalidates GFR calculator as creatinine can’t be used as indicator anymore

Question 5

Target and effect of gentamicin

Answer 5

Target: 30s ribosomal subunit
Effect: antibiotic - decreased translation of mRNA

Question 6

Effect of ACEi on glomerular pressure

Answer 6

Reduces glomerular by dilating efferent arteriole

Question 7

Target, location & effect of dapaglifozin

Answer 7

Target: SGLT2 inhibitor
Location: proximal convoluted tubule
Effect: reduced glucose reabsorption

Dependent on renal function

Question 8

How do NSAIDs affect renal function?

Answer 8

Decreases renal flow