Epigenetics

Question 1

Main Types of Epigenetic mechanisms

Answer 1

DNA methylation
Histone modification
chromatin-remodelling complexes
Non-coding RNA mediated gene-silencing

Question 2

Epigenetics

Answer 2

Heritable changes in our gene expression that do not alter our DNA .

Question 3

What does SRY expression drive

Answer 3

testicular differentiation

Question 4

Wollfian Ducts lead to…..

Answer 4

male internal and external genitalia

Question 5

Which genes are involved in the formation of the Testes

Answer 5

SOX9 on Chromsome 17

DAX1 on the X gene

Question 6

Do females require two X chromsomes for functional ovarian development

Answer 6

Yes, as seen in Turners (X,O) as the absence of the other X leads to streak non functioning ovaries

Question 7

AMH leads to regression of

Answer 7

Mullerian structures

Question 8

During Testes formation testosterone is used to

Answer 8

Testosterone promotes development of the Wollfian Duct into the epididymis, vas deferns and seminal vesicles
It is then converted to DHT which promotes development of several other structures

Question 9

Klinefelter Syndrome

Answer 9

XXY,
Infertile, Tall, Gynaecomastia
lack of secondary sexual characteristics