Enzyme Inhibition And Activation

Question 1

Organophosphorus compounds are what type of inhibitors, inhibiting what?

Answer 1

They are irreversible inhibitors

Inhibiting esterases (acetylcholinesterase)

Question 2

Can non competitive inhibitor be overcome by increasing substrate concentration?

Answer 2

NO

Question 3

What happens to the Km and vmax in competitive inhibition

Answer 3

Km = increases

Vmax= constant

Question 4

What happens to the Km and vmax in uncompetitive inhibition

Answer 4

Km= decreases

Vmax= decreases

Question 5

What happens to the Km and vmax in noncompetitive inhibition

Answer 5

Km= constant

Vmax= decreases

Question 6

Is there a counter regulation of substrate increase in uncompetitive and noncompetitive inhibition

Answer 6

No one there isn’t

Question 7

What is the difference between mixed and noncompetitive inhibition

Answer 7

Noncompetitive has equal affinity

Mixed shows preference

          ; for E and ES complex

Question 8

Example of regulatory enzymes

Answer 8

Phospholipases ll

Protein kinase C

Adenylyl cyclases