Enterobacteriacea Flashcards
how do people acquire EHEC?
enterohemorrhgic e coli
undercooked beef
unpaterurized milk
- diarrhea w/ ab pain
what is hemolytic uremic syndrome?
kidey failure 5-10% >10yrds
What toxin made by EHEC? reeptors?
2 shiga toxins
Stx1 and stx2 both have a and b subunit and dinds to G63 to inhibit protein synthesis
sttaching and effacing
lesions from shiga toxins
shigellosis?
shigellas most common disease gasroenteritis
what type of cells shigella invade and where do they replicate?
cell in the colon invade M cells
what 4 proteins shigella proteins secrete thu type 3 system
Ipa A B C D
these protein indice membran ruffling on the target cell leading to engulfment
how does shigella survive
shigella survive intercellularly by phagocytosis and apoptosis
apoptosis
programed death
S dysteriae what is the toxin and resceptor>
shiga toxin and b
a- aminoacyl transfer RNA
b- G63
how does shigella spread
person to person fecal-oral route
what population is at risk of shigella
pediatrics 60% >10
what disease is caused by yersinia pestis
bubonic plague. flea bite
pulmonary/pneumonic plague .person to person
y pestis is __
zoonotic infection
resovior rats, domestic animals
how are peole infected of yersenia pestis
- flea bites
- direct contact
- inhalation of infectous aerosol