Enteric Bacteria campylobacter/helico (3) Flashcards
Bacteriology of campylobacter
curved gram negative rods
motile
oxidase and catalase positive
What environmental conditions does campylobacter require to grow in?
microaerophilic - presence of low oxygen
What is the reservoir for campylobacter?
farm animals - ubiquitous
In contrast to diarrhea caused by cholera, what is the diarrhea like with campylobacter?
bloody - destructive intracellular infection
What complications follow bacteremia with campylobacter?
- guillain barre
- reactive arthritis
- HUS
- meningitis
- vascular infection
How would you diagnose a campylobacter infection?
- microaerophilic culture
- gram stain of fecal matter
- sigmoidoscopy
How do you treat a campylobacter infection?
rehydration
-add antibiotics if high fever or predisposed complications - immunosupressed, peds, worsening
Where does helobacter pylori colonize?
the stomach
What is the famous virulence factor of helobacter pylori?
urease: breaks down urea into ammonia
- ammonia neutralizes stomach acid
Why does H pylori predispose to ulcers?
destroys local cells and attracts massive inflam. infiltrate
What are some later complications of H pylori infection
gastric cancer and MALT lymphoma
Does H pylori always cause ulcers?
no infection is much more common than ulcer prevalence
How do you diagnose an H pylori infection?
scope, urea breath and/or PCR, biopsy
How do you treat an H pylori infection?
antibiotics and proton pump inhibitors
What is different btwn vibrio and campylobacter infection?
the reservoir: humans and ocean vs farm animals
- campylobacter is NOT able to grow at room temp
- campylobacter can produce reactive arthritis
