Endometrial Flashcards
What is the epidemiology of endometrial Ca?
Most common gynaecological malignancy
What are risk factors for endo?
Unopposed oestrogen
Age
Lynch syndrome
What is protective
OCP
What is the different between Type I and type II
II is less oestrogen dependent, poorer prognosis
What is the staging criteria used?
FIGO
How do patient classically present?
Abnormal PV bleeding
- Pelvic/abdo pain, bloating, systemic symptoms
What is the evidence for PET
Nil
What is the surgical procedure performed?
Total hysterectomy and bilateral salpingo-oopherectomy +/- sentinal node sampling for presumed early stage cancer
What is the role of adjuvant treatment?
Controversial
Depends on risk factors
What are risk factors for disease recurrence?
FIGO stage Histological subtype and grade Lymphovascular invasion Depth of myometrial invasion Age
What is the adj Rx for low risk
Observation
What is the adj Rx for mod risk
Brachytherapy
Which biomarkers do you look for?
ER/PR status
mismatch repair protein status
