Endocrino Flashcards

1
Q

Características inhibidores de disacaridasas

A

Acarbosa, Miglitol
EA –> maldigestión/malabsorción
CI –> sd intestino corto y sd malabsortivo
Ventajas –> SÍ en ICC, IRenal, I hepática

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2
Q

ADO clásicos que aumentan la liberación de insulina

A

Sulfonilureas y metiglinidas

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3
Q

Efectos adversos sulfonilureas y metiglinidas

A

Hipoglucemias
Aumentan riesgo de arritmias, demencia y caídas

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4
Q

Contraindicaciones sulfonilureas y metiglinidas

A

Insuficiencia hepática y renal, NO combinar con insulina
Relativas: ancianos, niños, demencia, IC

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5
Q

ADO clásicos que disminuyen la resistencia a insulina

A

Biguanidas (metformina) –> hígado
Tiazolidinadionas o inhPPAR –> músculo y adipocito

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6
Q

Efectos adversos metformina

A

Acidosis láctica
Disminuye absorción B12

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7
Q

Efectos adversos pioglitazona

A

Aumenta RCV, cáncer de vejiga y DMAE seroso

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8
Q

Contraindicacionees metformina

A

Insuficiencia de órgano
Deshidratación
Alcohólicos
Infección
Ancianos

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9
Q

Contraindicaciones pioglitazona

A

ICC, cardiopatía isquémica, insuficiencia hepática
NO combinar con insulina

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10
Q

ADO efecto incretina

A

iDPP4 (-gliptinas) y aGLP1 (-glutide)

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11
Q

Efectos secundarios iDPP4

A

Muy bien tolerados
Saxagliptina –>aumenta RCV

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12
Q

Efectos adversos aGLP1

A

Náuseas y vómitos
Pancreatitis aguda

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13
Q

Contraindicaciones aGLP1

A

AP TNE páncreas o cáncer medular de tiroides
Pancreatitis aguda

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14
Q

Características iSGLT2

A

-glifocina
Efecto glucosúrico
EA –> deshidratación hipernatrémica, ITU, candidiasis, CAD euglucémico
CI –> = EA, evitar en ancianos

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15
Q

Efectos adversos estatinas y fibratos

A

Musculares y hepáticos
Sinergia tóxica –> más seguro fenofibrato
CI insuficiencia renal

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