Endocrine system & endocrine emergencies Flashcards
This insulin type is immediate acting with a short duration, making it ideal for constant rate infusions, and can also be administered IV.
a. Porcine zinc insulin suspension (Vetsulin®)
b. Regular insulin
c. NPH insulin
d. Glargine insulin
B
Somogyi phenomenom, episodes of hypoglycemia followed by rebound hyperglycemia, should be treated by:
a. increasing the patient’s insulin dose
b. administering insulin TID instead of BID
c. decreasing the patient’s insulin dose
d. administering insulin SID instead of BID
C
Which of the following is a typical abnormality seen with hypoadrenocorticism crisis?
a. Hyperglycemia
b. Hypernatremia
c. Hyperkalemia
d. Azotemia
C
The signs and symptoms of typical hypoadrenocorticism are caused by inadequate secretion of:
a. glucocorticoids
b. mineral corticoids
c. both glucocorticoids and mineral corticoids
d. anabolic steroids
C
What test is used to confirm a hypoadrenocorticism diagnosis?
a. Basal serum cortisol
b. Fructosamine level
c. Adrenocorticotropic hormone test
d. Metanephrine level
C
In hyperosmolar hyperglycemic states, sodium concentrations should be reduced at what rate?
a. >0.5^mEq/L/h
b. <0.5^mEq/L/h
c. >0.2^mEq/L/h
d. <0.2^mEq/L/h
B
Inadequate control of diabetes mellitus would be indicated by a fructosamine level of which value?
a. 225^μmol/L
b. 280^μmol/L
c. 360^μmol/L
d. 540^μmol/L
D
Which of the following is not a ketone?
a. Acetyl CoA
b. Beta-hydroxybutyrate
c. Acetoacetate
d. Acetone
A
The formula [2 × (Na + K)] + (BUN/2.8) + (glucose/18) calculates what value?
a. Base excess
b. Base deficit
c. Serum osmolarity
d. Anion gap
C
A serum sodium to potassium ratio (Na:K) of <27 is indicative of which disease process?
a. Hyperadrenocorticism
b. Hypoadrenocorticism
c. Diabetic ketoacidosis
d. Hyperosmolar hyperglycemia syndrome
B
What makes up the endocrine system?
Adrenal glands
Parathyroid
Thyroid
CNS
GIT
Pancreas
Kidneys
Gonads
Placenta
Neurotransmitters….
Act locally to control nerve function and are released by axon terminals of neurons into the synaptic cleft
Endocrine hormones….
released by “glands” into circulating blood and influence the function of the target cells
Neuroendocrine hormones….
secreted by neurons and influence the function of their target locations
Paracrine substances….
Secreted by cells into the ECF and affect the function of neighbouring target cells of a different type
Autocrine substances….
Secreted by cells into ECF and affect the same cells which produce them
Cytokines….
proteins secreted by cells into the ECF that affect the immune system and can function as paracrine, autocrine or endocrine hormones
Three broad classes of hormones
- Proteins & polypeptides i.e. insulin & glucagon
- Steroids i.e. cortisol, aldosterone & testosterone
- Tyrosine amino acid derivatives i.e. thyroxine, epinephrine, norepinephrine
How are all endocrine secretions controlled?
Tightly controlled through feedback mechanisms
Hormone receptor location
Large proteins that life on the surface or in the surface of cell membranes, cytoplasm or nucleus
What or how much a hormone exerts depends on
- Rate of production or secretion
- Availability if transport plasma proteins
- Ability of target tissue to convert the hormone
- Availability of the specific receptor
- Breakdown of the hormone
- Liver/Kidney ability to excrete
Hypothalmic-pituitary axis (HPA axis)
Hypothalamus co-ordinates the endocrine system. It releases corticotropin releasing hormone (CTRH) & other major hormones which is received by the pituitary gland causing the release of ACTH, GH, prolactin, LG, FSH. ADH is secreted from the posterior gland. The adrenal glands are signalled to release cortisol
Diabetes mellitus pathophysiology
Type 1 is insulin -dependent (congenital, immune-mediated, idiopathic) whereas type 2 is destruction of pancreatic b-cells (obesity, genetics, islet amyloidosis, abnormal insulin response). Approx. 50-70% of DM cases are type 1 and insulin-dependent
Secondary forms of DM
Pregnancy
Carbohydrate intolerance
Acromegaly
Cushing’s disease