Endocrine System Flashcards
The endocrine system is responsible for the production and release of __________.
hormones
__________ hormones are associated with proteins in the bloodstream.
Lipid soluble
Endocrine hormones act on __________ cells.
target
The degree of association between lipid-soluble hormones and proteins can vary with the __________.
environment (pH, ions, etc.)
The __________ form of a lipid-soluble hormone is the active form.
free
Lipid-soluble hormones generally act via __________ receptors.
intracellular
Lipid-soluble hormones generally affect the synthesis of specific __________ within the cell.
proteins
__________ hormones act via specific receptors on the target cell membrane.
Hydrophillic
Hydrophilic hormone-receptor interaction activates __________ systems within the cell.
second messenger
The three chemical categories of endocrine hormones are amine, peptide, and __________.
steroid
Ultrashort-loop feedback regulation occurs when a hormone inhibits its own __________.
secretion
The two aspects of the dose-response relationship are responsiveness and __________.
sensitivity
Responsiveness refers to the __________ response.
maximum
Sensitivity refers to the concentration of hormone that produces __________ the maximum response.
half
A __________ effect occurs when one hormone allows another hormone to exert its full effect.
permissive
True or False: Both lipid-soluble and lipid-insoluble hormones act as first messengers.
True
Signal transduction mechanisms for lipid-insoluble hormones involve __________.
GPCRs
Signal transduction mechanisms for lipid-soluble hormones involve __________ hormone receptors.
steroid
G-protein coupled receptors produce more __________ effects, while steroid hormone receptors produce __________ response effects.
rapid, slower
The two types of enzyme-linked (catalytic) receptors are receptor tyrosine kinase and __________.
tyrosine kinase-associated receptor
The signal transduction mechanism for tyrosine kinase involves a __________ of intracellular signaling.
cascade
Steroid hormone receptors bind to specific DNA sequences called __________.
steroid response elements
True or False: Endocrine hormones are synthesized as needed and/or produced and stored for release as needed.
True
The steps in hormone signaling include stimulus, stimulus detection, hormone release, hormone processing, hormone detection at the effector cell, intracellular events, and __________ to the hormone signal.
response
The endocrine system consists of various __________ located throughout the body.
glands
Endocrine glands release hormones directly into the __________.
bloodstream
The __________ gland is often referred to as the “master gland” because it controls many other endocrine glands.
pituitary
The __________ gland produces hormones that regulate metabolism.
thyroid
The __________ glands produce hormones that regulate calcium levels in the blood.
parathyroid
The __________ glands produce hormones that regulate stress response.
adrenal
The __________ produces insulin and glucagon, which regulate blood sugar levels.
pancreas
The __________ produce estrogen and progesterone in females, and testosterone in males.
gonads (ovaries and testes)
Hormones travel through the bloodstream to reach their __________ cells.
target
Hormone receptors are specific __________ that bind to particular hormones.
proteins
Hormone binding to its receptor triggers a __________ of events within the target cell.
cascade
__________ feedback loops help to maintain hormone levels within a normal range.
Negative
__________ feedback loops amplify hormone production.
Positive
Endocrine disorders can result from either __________ or __________ of hormone production.
overproduction, underproduction
__________ is a condition characterized by high blood sugar levels due to insufficient insulin production or insulin resistance.
Diabetes
__________ disease is an autoimmune disorder that causes an overactive thyroid gland.
Graves’
__________ is a condition characterized by low thyroid hormone levels.
Hypothyroidism
__________ syndrome is caused by an overproduction of cortisol by the adrenal glands.
Cushing’s
__________ disease is caused by an underproduction of cortisol by the adrenal glands.
Addison’s
__________ hormone is essential for growth and development.
Growth
__________ hormones, such as estrogen and testosterone, play a key role in sexual development and reproduction.
Sex
The endocrine system interacts closely with the __________ system to regulate various bodily functions.
nervous
__________ are chemical messengers that act over short distances between neurons or between neurons and target cells.
Neurotransmitters
__________ are hormones produced by neurons that are released into the bloodstream.
Neurohormones
The __________ is a brain region that links the nervous and endocrine systems.
hypothalamus
True or False: Thyroid hormone is hydrophilic.
False, it’s lipophilic
The hypothalamus and the pituitary gland make up the _____.
Hypothalamic-pituitary axis
The posterior pituitary is also known as the _____.
Neurohypophysis
The anterior pituitary is also known as the _____.
Adenohypophysis
The _____ neurons produce primarily ADH.
superoptic
The _____ neurons primarily produce oxytocin.
paraventricular
_____ are carrier proteins that transport hormones from the hypothalamic nuclei to the posterior pituitary.
Neurophysins
ADH secretion is stimulated by signals from _____ and _____.
osmoreceptors, baroreceptors
Oxytocin and ADH use the _____ signaling pathway.
JAK/STAT
_____ from the hypothalamus stimulates GH secretion.
Growth hormone-releasing hormone (GHRH)
Somatostatin is also known as _____.
Somatotropin release-inhibiting hormone (SRIF)
Somatostatin (SRIF) _____ the release of growth hormone.
inhibits
Growth hormone secretion exhibits a _____ pattern of release.
cyclical/pulsatile
Growth hormone acts directly on target tissues and indirectly via the production of _____.
Insulin-like growth factor 1 (IGF-1)
The cells in the anterior pituitary that secrete growth hormone are called _____.
somatotrophs
The cells in the anterior pituitary that secrete prolactin are called _____.
lactotrophs
The growth hormone receptor utilizes the _____ signaling pathway.
JAK/STAT
GHRH acts on the anterior pituitary to stimulate the synthesis and release of _____.
growth hormone
The posterior pituitary hormones are synthesized in the _____.
hypothalamus
The posterior pituitary stores and releases _____ and ______.
ADH, oxytocin
A key difference between the anterior and posterior pituitary is their connection to the hypothalamus. The posterior pituitary has a _____ connection, while the anterior pituitary has a _____ connection.
neural, vascular
_____ increases water reabsorption in the kidneys.
ADH
_____ stimulates uterine contractions and milk ejection.
Oxytocin
Insulin-like growth factor 1 (IGF-1) primarily mediates the effects of _____ on _____ growth.
growth hormone, bone and soft tissue
Increased blood osmolarity stimulates the release of _____.
ADH
Decreased blood pressure stimulates the release of _____.
ADH
Suckling stimulates the release of _____.
oxytocin
Stress inhibits the release of _____.
growth hormone
Growth hormone promotes _____ nitrogen balance.
positive
Growth hormone increases _____ levels in the blood.
glucose
Growth hormone stimulates the production of _____ in the liver.
IGF-1
IGF-1 promotes _____ growth.
bone and soft tissue
The hypothalamic-pituitary axis is an example of a _____ system.
neuroendocrine
The hypothalamus releases _____ hormones that regulate the anterior pituitary.
releasing and inhibiting
_____ acts on the kidneys to conserve water.
ADH
_____ can stimulate milk production in lactating mothers.
Prolactin
Growth hormone deficiency in childhood can lead to _____.
dwarfish
Growth hormone excess in adulthood can lead to _____.
acromegaly
The hypothalamic neurons that produce ADH are located in the _____ nucleus.
superoptic
The hypothalamic neurons that produce oxytocin are located in the _____ nucleus.
paraventricular
Neurophysins are _____ proteins.
carrier
The primary target organ of ADH is the _____.
kidney
The primary target organs of oxytocin are the _____ and _____.
uterus, mammary glands
Cortisol is an example of a ____________.
glucocorticoid
Somatostatin inhibits the anterior pituitary to release _____.
growth hormone
The primary target of GHRH is the _____.
anterior pituitary
The primary target of somatostatin is the _____.
anterior pituitary