Endocrine pharm FA (INSULINS), injectable

Question 1

LISPRO? time

Answer 1

Rapid acting, 1h peak

Question 2

ASPART? time

Answer 2

Rapid acting, 1h peak

Question 3

GLULISINE? time

Answer 3

Rapid acting, 1h peak

Question 4

REGULAR? time

Answer 4

short acting, peak 2-3h

Question 5

NPH? time

Answer 5

intermediate acting, 4-10h

Question 6

detemir? time

Answer 6

long acting, no real peak

Question 7

glargine?

Answer 7

long acting, no real peak

Question 8

What bind insulin preparations?

Answer 8

insulin receptors (tyrosine kinase activity)

Question 9

Insulins on liver?

Answer 9

incr. glucose stored as glycogen

Question 10

insulins on muscle?

Answer 10

incr. glycogen, protein synthesis

Question 11

insulins on fat?

Answer 11

incr. TG storage

Question 12

insulins on cells membrane?

Answer 12

incr. K uptake

Question 13

insulins - adverse? 4

Answer 13

hypoglycemia, lipodistrophy, hypersensitivity reactions (rare), weight gain

Question 14

What is amylin analog?

Answer 14

pramlintide

Question 15

pramlintide (amylin analog) efect?

Answer 15

decr. glucagon release, DECR. GASTRIC EMPTYING -> incr. satiety

Question 16

GLP1 analogs? 2

Answer 16

exenatide, liraglutide

Question 17

exenatide, liraglutide group?

Answer 17

GLP1 analogs

Question 18

exenatide, liraglutide efect?

Answer 18

decr. glucagon release, DECR. GASTRIC EMPTYING -> incr. satiety

INCR. glucose-dependent insulin release

Question 19

pramlintide (amylin analog) adverse?

Answer 19

hypoglycemia (in setting of mistimed prandial insulin), nausea, GI upset

Question 20

pramlintide (amylin analog) when is used?

Answer 20

post-prandial

Question 21

exenatide, liraglutide adverse?

Answer 21

Nausea, vomiting, pancreatitis
Promotes weight loss (often desired)
Incr. satiety (often desired effect).