Endocrine pharm FA (INSULINS), injectable Flashcards
1
Q
LISPRO? time
A
Rapid acting, 1h peak
2
Q
ASPART? time
A
Rapid acting, 1h peak
3
Q
GLULISINE? time
A
Rapid acting, 1h peak
4
Q
REGULAR? time
A
short acting, peak 2-3h
5
Q
NPH? time
A
intermediate acting, 4-10h
6
Q
detemir? time
A
long acting, no real peak
7
Q
glargine?
A
long acting, no real peak
8
Q
What bind insulin preparations?
A
insulin receptors (tyrosine kinase activity)
9
Q
Insulins on liver?
A
incr. glucose stored as glycogen
10
Q
insulins on muscle?
A
incr. glycogen, protein synthesis
11
Q
insulins on fat?
A
incr. TG storage
12
Q
insulins on cells membrane?
A
incr. K uptake
13
Q
insulins - adverse? 4
A
hypoglycemia, lipodistrophy, hypersensitivity reactions (rare), weight gain
14
Q
What is amylin analog?
A
pramlintide
15
Q
pramlintide (amylin analog) efect?
A
decr. glucagon release, DECR. GASTRIC EMPTYING -> incr. satiety
