Endocrine Liver 5

Question 1

what are the two aminotransferases?

Answer 1

Aspartate AST & Alanine ALT aminotransferase

Question 2

how can aminotransferase levels determine liver damage?

Answer 2

contents of hepatocytes are released when damaged

Question 3

What does oxidative deamination yield?

Answer 3

ketoacids + ammonia

Question 4

How does a high protein diet effect the liver?

Answer 4

high AA –> urea production (ammonia + HCO3), high levels of ammonia are toxic

Question 5

How is alcohol metabolized by the liver?

Answer 5

ethanol –> acetaldehyde (via alcohol dehydrogenase) –> acetate & Cytochrome P-450 (ethanol–>aldehyde)

Question 6

How does the liver metabolize lipids?

Answer 6

triglycerides, cholesterol, long chain FA –> ATP, ketone bodies, cholesterol, lipoprotein & phospholipid synthesis

Question 7

What do Statins do?

Answer 7

inhibit HMG CoA reductase (rate limiting enzyme for cholesterol synthesis from acetyl CoA)