Endocrine Liver 2

Question 1

What does bile do for digestion?

Answer 1

lipid (fat) digestion & absorption of lipid soluble vitamins (A, D, E, K)

Question 2

What does bile do for excretion?

Answer 2

elimination of bilirubin, cholesterol, and drug metabolites

Question 3

How is cholesterol converted into a bile salt in the liver?

Answer 3

7-a-hydroxylase conversion of cholesterol to Primary Bile Acids (cholic acid/chenodeoxycholic acid) –> conjugation into Taurine or Glycine (Bile Salts)

Question 4

What happens to bile salts in the intestine?

Answer 4

can be unconjugated by Dehydration Rxn into Secondary Bile Salts (Deoxycholic Acid, Lithocholic Acid)

Question 5

What goes into the synthesis of bile?

Answer 5

Bile salts, H2O, glutathione, glucose, AA, urea, CHOLESTEROL, BILIRUBIN, Phosphatidylcholine (increases cholesterol solubility)

Question 6

Where are Cholangiocytes? What do they do?

Answer 6

line ductules - alter composition of bile: Reuptake (glucose, AA), Release (HCO3-, IgA)