Endocrine: Hypothalamus and Pituitary

Question 1

Growth Hormone Drug

Answer 1

Somatotropin

Question 2

GH drug’s uses

Answer 2

PW syndrome
CRF
Noonan Syndrome
Turner Syndrome

Question 3

Insulin like Growth Factor drug

Answer 3

Mecasermin
Use: IGF Deficiency
SE: Hypoglycemia

Question 4

GH Antagonists

Answer 4

Somatostatin
Octreotide
Pegvisomant (only Acromegaly)
Uses: Acromegaly, Gigantism, DM Diarrhea, WDHA, Carcionoid Syndrome (Gastrinoma), Bleeding Esophageal Varices

Question 5

Gonadotropins

Answer 5

UroFollitropin (uFSH)
Follitropin Alpha and Beta (rFSH)
Lutropin (rLH)
hCG
Uses: Ovarian induction, IVF
SE: Ovarian Hyperstimulation

Question 6

Prolactin

Answer 6

Blocked by Dopamine naturally

Makes milk

Question 7

Dopamine Agonists

Answer 7

Bromocriptine
Cabergoline
Pergolide
Uses: Hyperprolactinemia, Acromegaly, Sheehan Syndrome (Post Partum Hypopituitarism)

Question 8

Oxytocin

Answer 8

Labor Induction
Augmenting delayed labor
Milk ejection
Control hemorrhage after vaginal or cesarean delivery
Toxicity: Too many cramps may cause fetal distress, Fluid retention
CI: Fetal distress syndrome, Premie, Head too big for pelvis

Question 9

Vasopressin

Answer 9

ADH
V1: Vasoconstriction
V2: Renal fluid retention (prevent diuresis)
Desmopressin (Best against DI)

Question 10

Vasopressin Antagonist

Answer 10

Conivaptan
Tolvaptan
Uses: Hyponatremia, Heart Failure

Question 11

GnRH

Answer 11

Gonadorelin
Goserelin
Naferelin
Histrelin
Leuprolide
Uses: FSH & LH stimulation (Pulsatile), Inhibit Gonadotropin stimulation (continuous)
INC Gn for infertility
DEC Gn to assist repro technology
SE: Signs of menopause

Question 12

GnRH Receptor Antagonists

Answer 12

Ganirelix
Cetrorelix
Use: Prevent LH Surge (Ex: PCOD)