Endocrine Diseases

Question 1

Hypothyroidism

Answer 1

Thyroid hormones important to the skin, initiate anagen phase of hair follicle cycle.
Alopecia noted in areas of wear
Hair not growing back after clipping
Dull, dry brittle hair coat

Ridgebacks: pronounced striping
Recurrent pyoderma and otitis externa also common

Question 2

Hyperadrenocorticism

Answer 2

Excess cortisol - disturbances in cornification, dermal thinning, delayed wound healing
Bilateral symmetrical alopecia, skin easily bruises, visible dermal blood vessels, comedones, caliconosis cutis, increased susceptibility to pyoderma, adult onset demodex

Question 3

Calcinosis Cutis

Answer 3

General Term includes all dystrophic or metastatic calcification of the skin.
Generally secondary to hyperadrenocorticism or iatrogenic hyperglucocorticoidism.
Plaques and crusts to affected areas.
Has been reported in CRF
Generally resolves once underlying metabolic disturbance is removed.

Question 4

Feline Aquired Skin Fragility

Answer 4

Often associated with hyperadrenocorticism (often adrenal tumors), iatrogenic hyperglucocorticoidism, progestational compounds

Fragile, thin skin that easily bruises and tears with simple manipulations

Question 5

Hyperestrogenism

Answer 5

Increased estrogen from cystic ovaries, granulosa cell tumors, testicular tumors, iatrogenic estrogen supplementation, topical estrogen products.

Inhibits anagen initiation of hair follicles - alopecia
Can cause feminization of males
Tx - neuter, remove sources of estrogen

Question 6

Feline Paraneoplastic Alopecia

Answer 6

Association with pancreatic adenocarcinoma
Bilateral symmetrical ventrally pronounced alopecia (not shiny)
Dry, Scaly or fissured footpads in some cats
Older cats
Secondary Malassezia common
AUS for diagnosis

Question 7

Feline Thymoma associated Exfoliative Dermatitis

Answer 7

Rare
Middle - older cats with thymomas

Generalized erythema and marking scaling
Removal of thymine tumor will resolve Derm signs

Question 8

Nodular Dermatofibrosis

Answer 8

Syndrome characterized by general nodular dermatofibrosis associated with renal cystadnocarcinomas and cystadenomas.

Most often in German Shepherds and their crosses.
Middle age dogs 6 -8 years
Renal dysfunction can develop 3 - 5 years after skin issues first noted

Question 9

Paraneoplastic Pemphigus

Answer 9

Rare, severe blistering disease of mucosal surfaces, haired skin

Grave prognosis