Endocrine And Metabolic Dissorders Flashcards
What is Hyperadrenocorticism more commonly known as?
Cushing’s disease
What species is cushings disease most common in?
Dogs
What causes cushings disease?
Excessive cortisol in the body. Either due to excessive steroid use or an over production of cortisol by the adrenal glands
What can cause over production of cortisol by the adrenal glands in cushings disease?
A tumour on the pituitary gland (pituitary dependent HAC) which over stimulates the adrenal glands to produce cortisol
Or a tumour on the adrenal gland (adrenal dependent HAC)
What is the most common form of Hyperadrenocorticism ?
Pituitary-dependent HAC
What are the clinical signs of cushings disease?
Polyuria/ polydipsia Polyphagia Pot belly Panting Bilateral Alopecia and skin changes (thin inelastic skin) Muscle atrophy and weakness
What are the diagnostics for cushings disease?
Blood tests: haematology and biochemistry
ACTH stimulation test
Low-dose dexamethasone suppression test (LDDST)
High-dose dexamethasone suppression test (HDDST)
Endogenous ACTH assay
Abdominal ultrasonography
Abdominal radiography
MRI or CT (pituitary and adrenal areas)
What tests would be used to confirm cushings disease?
ACTH stimulation
LDDST
What tests would be used to differentiate between pituitary-dependent and adrenal dependent HAC ?
HDDST
ACTH assay
How would pituitary-dependent HAC be treated?
Medically with trilostane (veterinary licensed product) or mitotane (human-licences product) if there are complications
How can adrenal- dependent HAC be treated?
Drugs or surgical removal
What are the nursing care point for a patient with cushings disease?
Monitor vital and clinical signs Assist VS with diagnostic tests Observe after blood sampling for haematoma formation and handle carefully as brushing can occur easily Provide water Clan and groom as necessary Administer meds prescribes by VS
What is Hypoadrenocorticism more commonly known as?
Addison’s disease
Shat causes Addison’s disease?
A reduction in, or failure of steroid production by the adrenals
What causes the reduction of steroid production by the adrenals in Addison’s disease?
Usually immune destruction of the adrenal gland but may also be a consequence of treating Hyperadrenocorticism