Endocrine Flashcards

1
Q

MEN1

A

Mut MEN1 (tumor suppressor) LOF

Parathyroid adenoma (recurrent kidney stones) 
Pituitary adenoma
Pancreatic tumor (gastrinomas)
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2
Q

MEN2A

A

Mut RET (oncogene) tyrosine kinase GOF

Pheochromocytoma
Medullary thyroid carcinoma (C cells –> hypocalcemia)
Parathyroid adenoma

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3
Q

MEN2B

A

Mut RET (oncogene) tyrosine kinase GOF

Pheochromocytoma
Medullary thyroid carcinoma
Neuromas and Marfinoid appearance

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