Endocrine Flashcards
1
Q
MEN1
A
Mut MEN1 (tumor suppressor) LOF
Parathyroid adenoma (recurrent kidney stones) Pituitary adenoma Pancreatic tumor (gastrinomas)
2
Q
MEN2A
A
Mut RET (oncogene) tyrosine kinase GOF
Pheochromocytoma
Medullary thyroid carcinoma (C cells –> hypocalcemia)
Parathyroid adenoma
3
Q
MEN2B
A
Mut RET (oncogene) tyrosine kinase GOF
Pheochromocytoma
Medullary thyroid carcinoma
Neuromas and Marfinoid appearance