Endocrine

Question 1

Group of disorders caused by defect in 1 or more of enzymes required for cortisol synthesis.
Defects lead to overproduction of precursors in pathway and to excessive amounts of ACTH

Answer 1

Congenital adrenal hyperplasia

Question 2

Can have adrenal crisis with any stressor, including illness or surgery

Answer 2

Congenital adrenal hyperplasia

Question 3

Treatment for adrenal crisis

Answer 3

Immediate glucocorticoid administration at 2-3 times the maintenance dose