Endocrine

Question 1

iodide is actively absorbed from the blood by

Answer 1

“idoine pumping”

Na iodine SYMPORTER

Question 2

in pregnancy

total T4 and T3 will be ____

but Free T4 will be

Answer 2

T3/T4 will be increased

free T4 will be normal in pregnancy

Question 3

inc BMR by rate of inc Na/K-ATPase activity

Except in

Answer 3

brain gonad spleen

Question 4

how do you measure thyroid hormone

Answer 4

radioimmunoassay.

Question 5

PTU and Methimazole

treats hyperthyroidism how

Answer 5

inhibiton of organification of iodine

Question 6

hormone membrane receptors Q on boards

** oxytocin**

works on which G protein

Answer 6

g-protein Q

stimulates Gq –> inc phosphlipase C3 –> IP3

Question 7

Q on boards

what is the best method to identify estrogen receptors in breast tumor?

Answer 7

immunohistochemical detection of the estrogen receptor complex in the nuclei of the cells of the tumor

Question 8

whats the origin of the anterior pituitary

(adenohypophysis)

what tumor arises from the same origin?

Answer 8

ectoderm (rathke pouch)

craniopharyngioma

Question 9

what embryologic tissue does the posterior pituitary arise from?

Answer 9

neuroectoderm

Question 10

child with visual field changes (bitemporal hemianopsia)

mri (suprasellar calcifications)

you diagnosis craniopharyngioma

what do you expect on pathology

Answer 10

a lesion formed from cystic spaces filled with thick brown fluid rich in CHOLESTEROL“MACHINE oil fluid”

Question 11

female with a prolactinoma (pituitary adenoma) is at risk for

Answer 11

osteoporosis

bc dec estrogen due to inhibition of LH and FSH

Question 12

tx of prolactinoma

Answer 12

cabergoline, (long acting dopamine agonist)

bromocriptin

Question 13

on boards

pt with signs of prolactinoma

hypercalcemia (parathyroid adenoma)

recurrent duodenal ulcers not responding to tx (zollinger ellison syndrome)

diagnosis

Answer 13

men type 1

Question 14

all of the causes of inc prolactin

cause an increase of around 40-60

however one causes an inc above 200

what is it

Answer 14

prolactinoma

Question 15

hypothyroidism

can cause what prolactin to be increased how

Answer 15

prolonged hypothyroidism –> inc TSH and TRH –> dec dopamine –> inc prolactin

Question 16

estrogen dirctly inhibits what NT outflow

Answer 16

dopamine

thus this can cause inc in prolactin

Question 17

pt presents with complaint of impotence

he has chronic back pain for which he takes narcotics

why is he having impotence

Answer 17

bc opitates dec dopamine stores –> inc prolactin

Question 18

excessive growth hormone can cause inc in cartilage growth but not linear growth in adults causing

Answer 18

carpal tunnel syndrome

Question 19

carpal tunnel syndrome causes to know

Answer 19

1. cartilage growth in carpal tunnel by excessive GH
2. myxedema
3. pregnancy
4. RA
5. chronic kidney failure (due to B mycroglobulin deposit in the tunnel bc cant be excreted by dailysis)

Question 20

post partum women (just had baby) presents with

hypotension that doesnt correct with iv fluids

no hx of post partum bleeding

commonly pesents with hormonal def (ACTH)

Answer 20

lmphocytic hypophysitis

not sheehan bc no bleeding

Question 21

on boards

pt with panhypopituitariosm and hypotension after post partum bleeding

(due to loss of anterior lobe pituitary funciton)

diagnosis

Answer 21

sheenhan