immuno drugs Flashcards
1
Q
on boards
pt with either MS or Crohns disease
now pt is diagnosis with PML
what drug where they being treated with that caused this?
moa?
PML causes demylination of?
A
Natalizumab
(monoclonal antibody against cell adhesion molecule alpha4 integrin
this caused reactivation of JC virus that the pt was previously infected with in childhood
PML –> OLIGODENDROCYTE Demyelination
2
Q
question on boards
which monoclonal antibody that decreased T cell activation by binding to CD 3 is used in renal transplant pts?
A
Muromonab
3
Q
Q on boards
trick question
Cyclosporine or tacrolimus can be used in pts with renal transplant? what is there mechanism?
A. they decrease the number of CD4/CD8 cells
B. the decrease Activation of CD4/CD8 bc dec IL-2 production
A
dec activation T cells
4
Q
A
