Endo

Question 1

1st and 2nd line tx for pituitary adenoma

Answer 1

1st Dopamine agonist (bromocriptine)

2nd Surgical excision

Question 2

What is the precursor to insulin and what other substance is created along with it?

Answer 2

Proinsulin precedes Insulin and is cleaved into Insulin and C Peptide.

Ex. Exogenous administered insulin will have low C peptide levels since proinsulin did not cleave into the two.

Question 3

What site is affected in lithium toxicity

Answer 3

Collecting tube

Question 4

Difference between central DI and Nephrogenic DI

Answer 4

• Central is lack of ADS secretion from the pituitary

- Neprogenic is resistance to ADH

Question 5

MOA of desmopressin (DDAPV)

Answer 5

A synthetic analog of arginine vasopressin (DDAVP). It acts on the kidney to decrease urine output and reduce the subjective feeling of thirst in patients with diabetes insipidus.

Question 6

Drug used to treat DI

Answer 6

Desmopressin (DDAPV)

Question 7

What is found in the urine to diagnose pheochromocytoma?

Answer 7

Urinary vanillylmandelic acid (VMA) is a metabolite of catecholamines and is found in pheochromocytoma.

Question 8

Why is hyperprolactinemia associated with CKD

Answer 8

Prolactin is metabolized by the kidney therefore pts with CKD have excess prolactin