Embryology of the CVS - NOT COMPLETE Flashcards

1
Q

What does the heart begin as?

A

Bilateral heart primordia

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2
Q

What is the order of heart development?

A
  • Formation of the primitive heart tube
  • Heart looping
  • Atrial and ventricular septation
  • Outflow tract seperation
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3
Q

Which germ layer does the circulatory system originate?

A

Mesoderm

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4
Q

What part of the mesoderm does the circulatory system arise from?

A

Lateral plate splanchinic mesoderm

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5
Q

How does the two primitive heart tubes form?

A

Angiogenic cell islands move toward the midline and coalesce

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6
Q

Why is the heart one of the first functioning organ of the embryo?

A

Diffusion becomes diffucult as size increases

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7
Q

What areas of the embryo do blood vessels first appear?

A
  • Yolk sac
  • Allantois
  • Connecting stalk
  • Chorion
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8
Q

What tubes canalize to form the heart tubes?

A

Angioblastic cords

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9
Q

What does the pericardium develop from?

A

Intra embryonic coelom

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10
Q

What part of the mesoderm do the parietal and serous pericardium form from?

A

Somatic mesoderm

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11
Q

What layer of the pericardium forms from the splanchnic mesoderm?

A

The visceral layer

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12
Q

Describe the different layers of the primitive heart tube from arterial (cranial) end to venous (caudal) end

A
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13
Q

What way does the primitive heart tube loop?

A

Anti clockwise

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14
Q

Which two parts of the primitive heart tube grow the fastest to form the cardiac loop?

A

Bulbus Cordis and Ventricle hence the name bulboventricular loop

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15
Q

How does dextrocardia occur?

A

The heart tube loops to the left side instead of the right and eventuall then faces the right

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16
Q

What is endocardial cushion formation?

A

Seperates right atrioventricular opening from left atrioventricular opeing

17
Q

What two cardiac malformations can occur when endocardial cusion formation and septum formation go wrong?

A
  • Atrial septal defect
  • Ventricular septal defect
18
Q

Study the diagram referring to the left and right AV canals

A
19
Q

How does the primordial atrium partition into a left and right atria?

A

Formation of 2 septa and two foramina to eventually result in the fossa ovale

20
Q

What is the opening between the septum primum and the endocardial cushion called?

A

Ostium Primum

21
Q

What is the role of the foramina ovale before birth?

A

Allows blood to pass from the right to left atrium without entering the pulmonary system as the lungs are not functioning

22
Q

What is a clinical sign of atrial septal defect?

A

Blue baby

23
Q

How does blood not flow back through the septum?

A

Acts as a valve

24
Q

What are the four types of ASD?

A
  • Foramen secudnum defect
  • Endocardial cushion defect with foramen primum defect
  • Sinus venosus defect
  • Common atrium
25
Q

Describe the partitioning of the primordial ventricle

A
  • Muscular ventricular septum forms (opening known as interventricular foramen
  • Aorticpulmonary septum rotates and fuses with muscular ventricular septum to form membranous interventricular septum (this closes the interventricular foramen
  • Growth of endocardial cushion seperaties atria and contributes to the membranous portion of the interventricular septum
26
Q

What are the early heart pacemakers?

A

Primordial atrium then sinus venosus

27
Q

What does the AV node and bundle of his develop from?

A

Cells of AV canal and sinus venosus

28
Q

What can occur from abnormalities of the conducting syndrome?

A

Sudden infant death syndrome

29
Q

What does the aortic sac form?

A

Aortic arches

30
Q

What does the bulbus codis form?

A

Right ventricle and part of the outflow tracts

31
Q

What does the primitive ventricle form?

A

Left ventricle

32
Q

What does the primitive atrium form?

A

Parts of left and right atrium

33
Q

What does the sinus venosus form?

A

SVC

Right atrium

34
Q

What are the multifactorial aetiologies of congenital heart disease?

A
  • Rubella infection in pregnancy
  • Maternal alcohol abuse
  • Maternal drug treatment and radiation
  • Genetic
  • Chromosomal
35
Q

What is transpositiong of great vessels?

A

When the pulmonary trunk and the aorta join to the wrong ventrivle and the ductus arteriosis remains open

36
Q
A