Embryology Flashcards
How soon after ovulation does fertilisation occur?
12-24 hours
How soon after fertilisation does implantation into the endometrium occur?
5 and a half to 6 days
What is a fertilised ovum termed?
A zygote
A diploid cell arises from the fusion of 2 haploid gametes
What is a morula?
A solid mass of cells
How many days following fertilisation does a blastocyst form?
6-10 days
What is a blastocyst?
A hollow ball of cells (inner cell mass and trophoblast surrounding it)
What are chorionic villi?
The exchanger between the placenta and the mother
How many days following fertilisation does a morula form?
4-6 days
How is the baby’s blood replenished?
- From the mother’s blood via the placenta
- Blood circulations do not mix, they are separated by a thin barrier
- The barrier is permeable to most molecules (e.g. drugs) but not cells
What are the 2 layers of the bilaminar embryo?
- Epiblast layer
- Hypoblast layer
Why is it risky for a Rh- mother to have a Rh+ baby?
Blood circulations may mix during birth, foetal blood enters maternal circulation. Mother raises antibodies against Rh+ blood. Can put mother’s future Rh+ babies at risk (haemolytic disease of the newborn)
What does the epiblast give rise to?
The embryonic ectoderm, mesoderm and endoderm
What does the hypoblast do?
Participates on formation of endoderm and extraembryonic mesoderm
At approx 10-12 days, the implanted trophoblast contains an embryo which has 2 layers. What is this embryo termed and what are the 2 layers?
Bilaminar embryo
Layers are the epiblast and the hypoblast
What are the 2 types of twins?
- Identical/paternal: 1 sperm, 1 egg. Zygote splits in 2. Shared placenta. Same genetic makeup.
- Fraternal: 2 sperm, 2 eggs . Separate placentas. Different genetic makeup.
The bilaminar embryo is a disc. it has no orientation or axis. What does the embryo develop during gastrulation?
- An axis
- The 3 embryonic cell layers: ectoderm, endoderm, mesoderm
- Formation of a primitive streak
How is the mesoderm formed?
Ectodermal cells are induced to differentiate and migrate through the primitive streak towards the hypoblast. These new cells are the mesoderm
How is the endoderm formed?
Interaction between mesoderm cells and the hypoblast forms the endoderm
What is the embryo termed once is develops the 3 embryonic layers?
Trilaminar embryo