Eicosanoids and NSAIDs

Question 1

Misoprostil

Answer 1

• PGE derivative that increases mucosal cytoprotection

- used to treat GI ulcers

Question 2

Cloprostenol and Dinoprost

Answer 2

PGF2alpha derivative that causes lysis of corpus luteum and increases uterine contractions

Question 3

Travoprost and Latanoprost

Answer 3

• PGF2alpha derviative that increases drainage of intraocular fluids
• applied topically to eyes

Question 4

General beneficial actions of NSAIDs

Answer 4

• decreased vasodilation
• decreased local edema
• decreased sensitization of pain receptors to mechanical or chemical stimuli
• decreased pre-emptive and postoperative pain
• decrease in body temperature in febrile animals

Question 5

Tepoxalin

Answer 5

• inhibits COX-2 more than COX-1, but also 5-lipoxygenase activity and NF-kappaB actuation (i.e. inhibits prostanoid and leukotriene biosynthesis)
• anti-inflammatory and analgesic

Question 6

Aspirin

Answer 6

• irreversibly acetylates cyclooxygenase to decrease prostanoid formation
• has anticoagulant effects, analgesic, reduces fever, and has anti-inflammatory action

Question 7

Carprofen

Answer 7

• inhibits COX-2 more than COX-1

- anti-inflammatory and analgesic

Question 8

Deracoxib

Answer 8

• inhibits COX-2 more than COX-1

- anti-inflammatory and analgesic

Question 9

Flunixin

Answer 9

• inhibits both COX-1 and COX-2
• anti-inflammatory, analgesic, and antipyretic agent in large animals
• relieves visceral pain in dogs

Question 10

Phenylbutazone

Answer 10

• non-selective inhibitor COX-1 and COX-2
• anti-inflammatory and analgesic
• chondro-destructive effects