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Pharmacology Drugs > Cholinergic Drugs > Flashcards

Cholinergic Drugs Flashcards

1
Q

Pilocarpine

A
  • agonist of mAChRs, topical eye drug
  • promotes drainage of aqueous humor
  • reduces intra-ocular pressure
  • increases lacrimation
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2
Q

Bethanechol

A
  • agonist of mAChR

- stimulates urinary bladder motility and GI motility

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3
Q

Carbachol

A
  • agonist of mAChR

- stimulate rumen or colonic motility

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4
Q

Atropine and Scopolamine

A
  • tertiary amine-based mAChR antagonists
  • increase heart rate and AV conduction
  • bronchodilation
  • decreased tracheobronchial secretions
  • decreased salivation
  • decreased GI motility
  • pupillary dilation
  • decreased perspiration
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5
Q

Glycopyrrolate, Propantheline, Ipratropium, and Tropicamide

A
  • quaternary amine-based mAChR antagonists
  • increase heart rate and AV conduction
  • bronchodilation
  • decreased tracheobronchial secretions
  • decreased salivation
  • decreased GI motility
  • pupillary dilation
  • decreased perspiration
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6
Q

Nicotine

A
  • agonist of nAChR

- first stimulates, then blocks, autonomic ganglia and neuromuscular transmission

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7
Q

Levamisole

A
  • agonist of nAChR

- depolarizing neuromuscular blocker resulting in muscle paralysis

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8
Q

Edrophonium

A
  • antagonist of nAChR
  • used to diagnose myasthenia gravis
  • inhibitory effects on sympathetic and parasympathetic autonomic neurotransmission
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9
Q

Pyridostigmine

A
  • agonist of nAChR

- used to treat myasthenia gravis

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10
Q

Neostigmine

A
  • agonist of nAChR
  • reversibly inhibits acetylcholinesterase by acting at the esteratic site of the enzyme
  • used in treatment of myasthenia gravis
  • can reverse neuromuscular blockade produced by curariform drugs
  • stimulates GI and bladder motility
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11
Q

D-Tubocurarine

A
  • antagonist of nAChR

- neuromuscular junction blocker

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12
Q

Pancuronium

A
  • antagonist of nAChR
  • neuromuscular junction blocker
  • also blocks mAChR leading to tachycardia
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13
Q

Vecuronium

A
  • antagonist of nAChR
  • neuromuscular junction blocker
  • similar potency to pancuronium
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14
Q

Atracurium

A
  • antagonist of nAChR
  • neuromuscular junction blocker
  • similar to vecuronium
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15
Q

Succinylcholine

A
  • agonist of nAChR

- stimulates, then desensitizes, muscle nAChRs leading to skeletal muscle paralysis

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Pharmacology Drugs (10 decks)

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