ED Flashcards
Arterial supply of penis
pudendal artery –> common penile artery -> superficial dorsal artery and deep cavernosal artery
Penile innervation
Parasympathetic (S2-4)
ED risk factors
Vascular Disease Diabetes Medications Neurogenic Pelvic surgery/radiation Endocrine
Medications associated with ED
Cardiac - ____
Psych - ____
Urologic - ____
CCBs, Beta blockers, Digoxin, Diuretics
SSRIs, Benzos
ADT, Finasteride
PDE5-is promote erections by inhibiting breakdown of ___ to ___
cGMP –> GMP
____ catalyzes guanyl cyclase to synthesis GMP –> cGMP to promote smooth muscle relaxation & erectile function
NO
Levitra & viagra must be taken ____ eating
before eating on an empty stomach
no food effect for Cialis
Onset of Viagra is ___ minutes
Onset of Cialis is ____ minutes
Viagra = 60 min
Cialis = 120 min
Contraindications to PDE5is
Poor cardiac function
Nitrates
PDE-5i side effects
Facial flushing GI effects (Heartburn) Nasal congestion Visual disturbances (diplopia, changing colors) Myalgia
What are the 3 drugs in trimix and their mechanisms of action?
PGE1: cAMP activator
Papaverine: non‐specific PDE inhibitor
Phentolamine: alpha blocker
Trimix side effects
Pain from PGE1
Bruising
Priapism
Mechanism of intraurethral MUSE
PGE-1
Side effects of MUSE
Priapism Urethral bleeding Penile pain (PGE1 hypersensitivity) Inconsistent response Vaginal irritation
Vacuum device contraindications
Poor penile sensation (SCI)
Poor cognitive function
Peyronie’s
Anti-coagulation
