DSD

Question 1

Kidneys produce urine at week ___ of development

Answer 1

12

Question 2

Kidneys develop from ___derm

Answer 2

meso

Question 3

____ develops into the collecting system & ureter

Answer 3

ureteric bud

Question 4

Kidneys begin to ascend around week ___ of development

Answer 4

6

Question 5

Failure of contact between ureteric bud & metanephros leads to ____

Answer 5

renal agenesis

Question 6

Abnormal contact between ureteric bud & metanephros leads to ____

Answer 6

dysplastic kidney

Question 7

Multicystic dysplastic kidney is associated with other GU anomalies such as ___, ___, and ___

Answer 7

VUR, seminal vesicle cysts, Gartner’s duct cysts

Question 8

Ureteric bud misplacement leads to ___ or ___

Answer 8

VUR or ectopic ureter

Question 9

Ureteric bud duplications leads to _____

Answer 9

duplicated collecting system

Question 10

The effect of ___ allows gonads to descend below inguinal ring

Answer 10

testosterone

Question 11

At week ___, SRY gene flips the switch to allow for male differentiation

Answer 11

6

Question 12

Sertoli cells secrete _____ during development

Answer 12

MIS (mullerian inhibiting substance)

Question 13

____ is necessary for wolffian duct development

Answer 13

Testosterone

Question 14

External genitalia are undifferentiated until week ___ of development

Answer 14

8

Question 15

CAH is due to defect in _____

Answer 15

21-hydroxylase

Question 16

CAH leads to virilization in genotypic, ____, individuals

Answer 16

46XX

Question 17

Bilateral testes, female external genitalia

Answer 17

AIS (Androgen Insensitivity), 46XY

Question 18

One testis & one ovary, various external genitalia

Answer 18

46XX, ovotesticular dysgenesis

Question 19

46XX, normal external genitalia, bilateral streak gonads

Answer 19

pure gonadal dysgenesis