Ectopic Pregnancies Flashcards
What is the most common location of an ectopic pregnancy?
Tubal–ampullary part
True or false: generally, ectopic pregnancies do not survive
True
Which part of the tube do tubal pregnancies generally end up in?
Ampulla
What is the prevalences of ectopic pregnancies?
2% of all pregnancies
What are risk factors for the development of an ectopic pregnancy?
- PID
- IVF
- Prior ectopic
- Prior tubal surgery
What is the most common cause of first trimester pregnancy related deaths
Ectopic pregnancies
What percent of 1st semester bleeding is the result of ectopic pregnancies?
6-16%
What type of bleeding is seen in tubal rupture 2/2 ectopic pregnancy?
Hemoperitoneum (no vaginal bleeding)
Women of color have a (__)x higher risk of mortality from ectopic pregnancies.
5x
Ectopic pregnancies have a (__)x greater risk of maternal death than abortion.
50x
Ectopic pregnancies have a (__)x greater risk of maternal death than childbirth
10x
What is the relationship between IUD use and the incidence of ectopic pregnancies?
Lower overall pregnancy rate, but if pregnant, then higher chance of ectopic
True or false: smoking increases the risk for an ectopic pregnancy
True
True or false: multiple sex partners increases the risk for ectopic pregnancies
True
Why are prior PID, multiple sex partners, and prior tubal surgery all risk factors for the development of an ectopic pregnancy?
Prior uterine damage and scarring from trauma or infection
What are the three common presentations of an ectopic pregnancy?
- 1st trimester bleeding
- Abdominal/pelvic pain
- Asymptomatic
How do you diagnose an ectopic pregnancy?
- US see no live pregnancy
- hCG levels are high (1500-2000)
When should an ectopic pregnancy be suspected?
- 5-6 weeks from LMP
- 2 weeks after positive UPT
What is the usual trend of beta-hCG throughout pregnancy?
Rapid rise in the first trimester, doubling about every 48 hours.
Plateau around 10 weeks, the slowly fall
What, generally, occurs with hCG levels in an ectopic pregnancy?
Rise, but not as fast as normal pregnancy
What level of progesterone levels are indicative of a normal and ectopic pregnancy?
- Less than 5ng/ml = no normal pregnancies
- More than 25 ng/ml 97% of viable pregnancies
At what level of hCG should you be able to detect a pregnancy with TVUS? Abdominal?
2500 with TVUS
6000 with abdominal US
When can the gestational sac be seen with TVUS?
4.5 weeks
When can the yolk sac be seen with TVUS?
5 weeks
When can the embryo be seen with TVUS?
6 weeks
When can fetal heart tones be seen with TVUS?
6 weeks
When is hemolysis from Rh status a concern?
When mother is Rh - with an Rh + fetus
What is the uterine cul-de-sec?
Space between the rectum and the uterus
What happens to the ovary with ovulation?
May develop a luteal cyst that is visible on US
What is the drug that can be used to abort a fetus in case of maternal distress? Is it useful for ruptured pregnancies?
Methotrexate
Useless for ruptured pregnancies
Does the use of methotrexate preserve fertility?
Yes
Is methotrexate safe for BF mothers?
No
Can methotrexate be used in patients with immunodeficiencies?
No
What are the GI diseases that contraindicates methotrexate use? (2)
PUDs
Chronic liver disease
Can methotrexate be used in patients with acute pulmonary disorders?
No
An unruptured mass of greater than (__)cm is a contraindication to methotrexate.
3.5 cm
True or false: fetal cardiac activity is an aobsoulte contraindication to methotrexate use
False– relative. will not be as effective
Quant hCG level greater than what amounts is a relative contraindication to methotrexate use?
6000-15000
What is the dose used for methotrexate?
Single IM dose of 50 mg/m^2
How do you follow methotrexate use?
Serial quant beta-hCG should decline by 15% by day 7. Repeat or move to surgery
What are the side effects of Methotrexate use?
GI s/sx, including abdominal pain-thus should warn pt
What happens to hCG levels with methotrexate use?
Rises initially, but should decline after 4 ish days
What are the signs that methotrexate treatment is failing? (3)
- Significantly worse abdominal pain
- Hemodynamic instability
- beta hCG not declining 15% by day 7
What is a salpingotomy, and what are the risks benefits of it compared to a salpingectomy?
Making a hole in the fallopian tube to remove ectopic pregnancy.
increases the risk of a second ectopic
What is the recurrence rate of ectopic pregnancies after salpingotomy/salpingectomy? What should be done to monitor these patients in future pregnancies?
- 15-20%
- Monitor with early US and hCG levels