EBM Day 6

Question 1

web of causation

Answer 1

fight against 1 factor to 1 disease hypot

Idenfiy prevention/modifiable steps

Question 2

Suff vs Nec

Answer 2

Effect will result regardless of the presence or absence of other factors

Without it the effect will not occur
(need other factors for even to occur)

Question 3

Koch’s postulates

Answer 3

Can find microorg in sick, can isolate, can make orgs sick, can be re-isolated

not useful for chronic diseases

Question 4

BH critera-8

Answer 4

Temporatlity-req-need disease to be after exposure

Str or assoc-strong assoc better than weak

Dose response-expsure up, disease rate up
-threshold response

Reversibility
-remove exposure decrease rate of disease

Consistency-results are consistent across dif populations-

Plasubility-obvious

Specifity-exposure associated with disease outcome-super useless

Analogy=cause is analogous to other established causal relationships

Question 5

eco studies

Answer 5

aggregate studies

group analysis

missing expsoure and outcome on individual level

Question 6

Ecologic fallacy

Answer 6

all we have is avg values and rates-nothing about individualls
-can not ascribe group characteristics to indiv members of group (unless group is homogeneous)

Question 7

Metanalysis vs Quantitative Pooled Analysis

Answer 7

use other peoples data to establish better belief in things

Combine raw data-increase power and precision
-better to have studies with common protocol

Question 8

Best to worst studies

Answer 8

RCT
Nonrandomizd trails
Meta/pooled analysis
prospective cohort
retro cohort
case control
cross-sectional
eco
case series

Question 9

Qualitative Reviews

Answer 9

Qualitatively determine adv of treatment-kinda systematic

-objective

Question 10

Systematic reviews

Answer 10

Look at evidence and determine how affective is an exposure

• subjective
• most things have not enough evidence