E. coli Flashcards

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1
Q

what does E. coli synthesize in the human body?

A

vitamin K

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2
Q

name seven pathogenic E. coli:

A

1) EHEC - enterohemorrhagic
2) STEC - shiga toxin
3) EPEC - enteropathogenic
4) EAEC - enteroaggregative
5) EIEC - enteroinvasive
6) ETEC - Enterotoxigenic
7) DAEC - diffuse adhering

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3
Q

STEC/EHEC serogroups

A

O157:H7, O111, O26, O157:H-, O104:H4 (Germany)

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4
Q

STEC/EHEC places of infection

A
  • food
  • petting zoos
  • person to person
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5
Q

STEC/EHEC infectious dose

A

very low

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6
Q

Do STEC/EHEC have T3SS?

A

yes

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7
Q

what is the pathogenicity island for T3SS called in STEC/EHEC?

A

LEE

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8
Q

What does LEE encode?

A

intimin and tir

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9
Q

what is tir?

A

T3SS secreted bacterial protein that is delivered tot he sure of the epithelial cells to allow for E. coli attachment

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10
Q

what is intimin?

A

on the surface of E. coli and binds to tir

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11
Q

what can cause HUS (hemolytic uremic syndrome)?

A

shiga toxin or shiga-like toxin in E. coli dysenteriaea

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12
Q

symptoms of EHEC/STEC

A
  • abdominal pain
  • bloody diarrhea
  • HUS
  • acute renal failure
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13
Q

STEC and EHEC are grouped as:

A

enterohemorrhagic E. coli

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14
Q

what are the diarrheagenic E. coli?

A
  • EPEC
  • ETEC
  • EAEC
  • EIEC
  • DAEC
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15
Q

characteristics of EPEC

A
  • person to person contact
  • leading cause of diarrhea in developing countries
  • forms A/E lesions
  • toxins not detectable in stool
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16
Q

characteristics of ETEC

A
  • traveler’s diarrhea
  • enterocytes in SMALL INTESTINE
  • produces heat labile and heat stable toxins (LT and ST) which lead to fluid loss
17
Q

characteristics of EAEC

A
  • similar to EPEC but somewhat more aggressive due to stronger epithelial attachment
  • no A/E lesions
  • EAST and hemolysin produced
18
Q

characteristics of EIEC

A
  • symptoms similar to shigella

- no LT or ST produced

19
Q

characteristics of DAEC

A
  • diarrhea in older children in developing countries
20
Q

Does E. coli ferment lactose?

A

yes

21
Q

treatment of ETEC

A

loperamide (may be combined with fluoroquinolones)

22
Q

treatment of EAEC

A

fluorquinolones for traveler’s and those with HIV