Dyspnea CBM and Oxford Flashcards

1
Q

What is dyspnea?

A
  • subjective sensation
  • uncomfortable awareness of breathing.
  • Does not correlate with clinical or lab measurements
  • Based on stimulation of neuropsychological pathways
  • conscious perception of stimuli
  • interpretation of symptom in context of prior life experiences
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2
Q

Pathophysiology of dyspnea

A
  • Stimulation of mechanoreceptors, chemoreceptors, vagal afferents
  • impulses transmitted to sensory cortex and respiratory centre in medulla
  • Signals sent to motor cortex and respiratory muscles AND within sensory cortex
  • = conscious perception of shortness of breath
  • Experience of breathlessness affected by:
    • previous experiences
    • meaning of breathlessness
    • mismatch between ventilatory demand and body’s ability to respond
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3
Q

Prevalence of dyspnea

A
  • COPD 95%
  • CHF 61%
  • Stroke 37%
  • ALS - 50%
  • Dementia 70%
  • Cancer 46-70%

Depends on underlying disease, comorbidities and stage of disease

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4
Q

COPD Risk Factors (CBM)

A
  • cigarette smoking (1 ppd- 15% risk of COPD, 2ppd 25% risk)
  • passive cigarette exposure
  • occupational exposure
  • alpha anti trypsin deficiency
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5
Q

What abnormalities might you see on a Chest Xray of a person with COPD?

What pulmonary functiont tests confirm the diagnosis?

A
  • CXRAY:
    • normal
    • increase AP diameter of chest
    • Hyperinflation
    • flattening of diaphragm
  • PFTs:
    • FVC (lung volume)
    • FEV1 (airflow obstruction)
    • FEV1/FVC < 70% of the predicted value
      • MODERATE COPD FEV1 >/ 50%
      • SEVERE FEV1 35-49%
      • VERY SEVERE FEV1 34 %
    • FEV1 increases by 15% after bronchodilators = significant response
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6
Q

What are the management goals in COPD?

A
  1. To improve symptoms by decreasing airflow obstruction and airway inflammation
  2. To prevent secondary complications like infection
  3. To maintain function
  4. To improve QOL
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7
Q

What is the mechanism of action for B2 agonist and an anticholinergic? (CBM)

A

Beta2-agonists

  • bronchodilation via stimulation of B2 adrenergic receptors in airways
  • Used on as needed basis
  • rapid onset, short half life
  • SE: tachycardia, anxiety

Anticholingergics

  • Bronchodilation via inhibiting cholingeric mediated bronchmotor tone
  • inhibits vagally mediated bronchoconstrictions
  • REgular initial therapy
  • stronger bronchodilator effects, longer half life, fewer SE than B2 agonists
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8
Q

Vaccination in COPD

A
  • respiratory infection can precipitate airway inflammation - trigger COPDAE
  • high risk of infection in COPD
  • influenza: secondary bacterial pneumonia
  • influenza: increased risk of MI, arrythmia, stroke (cytokines)
  • vaccine efficacy 70% reduction in morbidity
  • Streptococcus pneumonia : CAP
    • pneumococcal vaccine q10 years.
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9
Q

Pulmonary rehabilitation for COPD

A
  • teaching correct inhaler technique
  • breathing and relaxation
  • energy conservation
  • nutritional guidance
  • exercise program
  • breathing techniques:
    • tripod breathing imrpoves efficiency by improving the length-tension dynamic of diaphragm
    • pursed lip breathing slows RR, increases intra-airway pressures
  • rehab programs outcomes:
    • decrease breathlessness
    • imrpoved exercise tolerance
    • better QOL
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10
Q

Home 02 in COPD

A

COPD patients with daytime hypoxia may have increased survival with 02.

  1. Continuous 02:
  • Pa02 < 55 mmHg or 02 sat < 88% at rest
  • Pa02 56-59 mmHg or 02 sat 89% IF:
    • polycythemia
    • cor pulmonale
    • pulmonary hypertension
  1. Intermittent 02:
  • Pa02 <55 mmHg or 02 sat < 88% during exertion
  • Pa02 < 55 mm Hg or 02 sat < 88% during sleep
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11
Q

Malnutrition and COPD

A
  • respiratory muscle wasting
  • weakness
  • Re-feeding, reconditiong, anabolic steriods
  • pulmonary rehab
  • Cachexia treatment
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12
Q

What is the 1 year mortality of COPD patients with FEV1 < 1 L?

A

30%

(worse than many cancers)

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13
Q

Superior Vena Cava Syndrome: clinical diagnosis

A
  • clinical severity:
    • degree of narrowing of SVC
    • speed of onset
    • adequacy of venous collaterals
  • dyspnea
  • facial, neck, arm swelling
  • Facial plethora
  • dilation and tortuostiy of veins of upper body
  • cyanosis of face.
  • orthopnea
  • cough
  • headaches
  • stridor /hoarseness
  • nasal congestion/rhinorrhea
  • proptosis
  • severe: cerebral edema
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14
Q

SVC syndrome : diagnostic tests

A
  • malignancy > 90% of cases
    • NSCLC 50%
    • SCLC 25%
    • Lymphoma and metastatic lesions (breast most likely) 10%
    • Thrombosis of SVC
  • CT with contrast
  • Tissue diagnosis if needed:
    • peripheral biospy
    • perc biopsy peripheral lung mass (75%)
    • bronchoscopy (50-70% dx yield)
    • mediatstinoscopy (90%)
    • open lung biospy
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15
Q

SVC syndrome : managment

A
  • treat malignancy
    • radiation
    • chemotherapy
    • SCLC = chemo fast
  • elevate head of bed
  • 02
  • fan/02
  • Dexamethasone 8mg po bid
    • case reports only
    • do not give BEFORE diagnosis: lymphomas highly sensitive to dex
  • Diuretics NOT recommended:
    • reduce preload, hypotension and shock, increased thrombosis
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16
Q

What are the clinical findings of Airway Obstruction?

A
  • tachypnea
  • increased WOB, accessory muscle use
  • tracheal deviation to IPSILATERAL side of collapse/obstruction
  • IPSILATERAL no air entry
  • IPSILATERAL absent tactile and vocal fremitus
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17
Q

What treatment options exist if there is an endobronchial obstruction?

A
  • external beam Radiation
  • laser
  • electrocautery
  • cryotherapy
  • endobronchial irradiation
  • photodynamic therapy
  • tracheobronchial stenting
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18
Q

What are the clinical findings of Pleural Effusion?

A
  • Tachypnea
  • Accessory muscles
  • Shallow breathing
  • CONTRALATERAL tracheal deviation (fluid pushing it away)
  • dulllness to percussion
  • decreased tactile and vocal fremitus
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19
Q

Pleural Effusion treatment

A
  • Thoracentesis
    • pleural fluids: cell count, cytology, LDH, protein, pH, culture and sens.
    • > 1.5 L may cause pulmonary edema
  • Chest tube to drainage:
  • Pleurex indwelling catheter
  • Pleurodesis:
    • sclerosing agent talc to create inflammation
    • pleura stick together
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20
Q

Define lymphangitic carcinomatosis

A
  • diffuse infiltration and obstruction of pulmonary parenchymal lymphatic channels by tumour
  • Non specific interstitial pattern on CXRAY
  • CXRay can be normal
  • high resoluation CT
21
Q

Lymphangitic carcinomatosis : managment

A
  • oncological treatment
  • corticosteroids
  • diuretics
  • poor prognosticator
22
Q

Dyspnea: Opioids - mechanism of action

A
  • Oral/parenteral opioids
    • Jennings et al. 2001. Opioids for the palliation of breathlessness in terminal illness. Cochrane Database of Syst Review; Issue 4, CD002066.
    • no benefit of nebulized opioids
  • Mechanism of action of opioids in dyspnea
    • change perception of breathlessness
    • decrease in 02 consumption
    • fall in ventilatory drive
    • reduced response to stimuli like hypoxia and hypercapnia
  • Cochrane review: 02 and c02 levels did not change with introduction of opioids
    • depends on tolerance, rate of dose increase, possiblly route of adminstration.
23
Q

Dyspnea management : oxygen in palliative care

A
  • Oxygen
    • hypoxia + dyspnea - clear evidence for 02 (survival benefit in copd)
    • Not recommended for hypoxia NO dyspnea
    • Non hypoxia + dyspnea = fan, humidifer, air by NP
    • Non hypoxia + dyspnea = trial humidified 02 by NP if fan fails.
  • Palliative 02 - 02 for symptom relief without hypoxia
  • Advanced cancer - 02> air in some studies
  • COPD no hypoxemia - individual basis
  • Mixed diagnosis - no benefit of 02 over air
  • CHF - no clear benefit
24
Q

Other medications for dyspnea? Phenothiazines

A
  • Phenothiazines : second line agents
  • Oral promethazine
  • Methotrimeprazine (oral or subQ)
  • Chlorpromazine (oral , IV)
  • NOT Prochlorperazine (WHY?)
  • No trials, clinical practice only
25
Q

Terminal respiratory secretions

A
  • loss of ability to clear secretions
  • pooling in oropharynx and bronchi
  • Normal
  • Reposition
  • Gentle suctioning of oropharynx only
  • No deep suctioning
  • Anticholinergics (anti muscarinic)
    • Hyoscine hydrobromide (scopolamine) - BBB –> delirium
    • Glycopyrrolate –> less delirium
26
Q

Define 3 qualities of dyspnea

A
  • Air hunger
    • conscious perception of urge to breathe
    • motor drive of respiratory centres in brainstem send signal to cerebral cortex
    • If not matched with adequate ventilation from feedback from afferent receptors in resp system__> air hunger
  • Work/effort
    • uncomfortable sense of respiratory effort
    • resp muscle afferents and perceived cortical motor demand
  • Tightness
    • bronchoconstriction
    • pulmonary afferents through the stimulation of airway receptors
27
Q

Where on neuroimaging (PET, fMRI) is activated in dyspnea?

A
  • R anterior insula
  • Amygdala
28
Q

History and Physical for Dyspnea

A
  • History:
    • intensity
    • quality (episodic, constant)
    • associated distress
    • impact on life
    • concerns of patients and caregivers
  • Physical
    • Severe signs :
      • stridor
      • tachypnea
      • tachycardia
      • Resp distress
      • ALOC
29
Q

Investigations in dyspneic patients

A
  • hemoglobin
  • 02 sat
  • CXRay
  • Rare abg
  • PFTs
  • Echo
  • Doppler
  • CT
30
Q

List three ways to measure dyspnea (American Thoracic Society)

A
  • Sensory - perceptual experience
    • rating of symptom intensity
  • Affective distress
    • Immediate distress or cognitive (long term) distress
  • Symptom impact
    • QOL
31
Q

List malignant and paramalignant causes of dyspnea and treatment

A
  • Lung cancer - chemo, targeted therapy
  • Metastatic disease to lung - chemo, etc
  • Pleural effusion - thoracentesis, pleurodises, PleurX cath
  • SVCO - Radiation, stents, chemotherapy, steroid
  • PE- LMWH
  • Pericardial effusion - pericardiocentesis, pericardiotomy
  • Major airway obstruction - stent, radiation, steroids, cryotherapy, laser therapy
  • Lymphangitic carcinomatosis - chemo, steroid
  • Radiation induced pneumonitis - steroid
  • Drug induced pneumonitis - steroid
  • Chest infection (PNA, empyema) - antibiotics

Systemic malignant causes

  • Cancer cachexia - prevent aspiration
  • Ascites - paracentesis
  • Hepatomegaly - prop up position
32
Q

List non malignant causes and treatment of dyspnea

A
  • COPD - rehab, LABA, SABA, inhaled steroid, phosphodiesterase inhibitors
  • Bronchiectasis - airway clearance, antibiotics
  • Interstitial pulmonary fibrosis - steroids
  • CHF - ACE, BB, hydralazine, nitrates, ARB, Spironolactone, digoxin, diuretics
  • Arrythmias - antiarrythmics, cardioversion

Systemic causes

  • Muscle weakness motor neuron disease - NIV
  • ALS - NIV
  • Muscular dystrophy - NIV
  • Anemia - transfusion, iron, erythropoeitin
  • Acidosis - Bicarb
  • Deconditioning - exercise, rehab
  • Panic attack - CBT, benzo
33
Q

Management of dyspnea - non pharmacological

A

Some good evidence

  • Breathing training
    • pursed lip breathing, diaphragmatic breathing, positioning, pacing
  • Walking aids
  • Neuromuscular electric stimulation
  • Chest wall vibration
  • Exercise

Some not so good evidence

  • Handheld fan (Randomized cross over trial)
  • Nurse follow up program
  • Acupuncture

No good evidence

  • relaxation
  • music
  • counselling
  • psychotherapy
34
Q

Dyspnea- opioids - clinical indications, dosing

A
  • best evidence for advanced cancer, COPD
  • CHF - conflicting evidence
  • Motor neuron disease, ILD - anecdotal reports only
  • No evidence for nebulized opioids
  • Starting dose variable
  • Morphine SR 10 mg most studied
  • Increase of 25% of patients already on opioids
  • Fentanyl for incidental breathlessness
  • Choose dose based on:
    • renal function, hepatic function, frailty, resp failure
    • usually lower dose for dyspnea than for pain
35
Q

List other medications for dyspnea?

A
  • Benzodiazepines
    • role for patients with anxiety + dyspnea
  • Inhaled furosemide
    • enhanced pulmonary receptor activity, suppression of pulmonary irritant and vasodilation
    • may be useful for dyspnea in airway diseases (asthma, copd)
    • no clear evidence for use in cancer
  • Heliox
    • low density, improves ventilation by replacing nitrogen
    • works for lung cancer, COPD already responding to 02
    • expensive and not available, limited clinical use
36
Q

Palliative use of Non Invasive Ventilation

A
  • AECOPD with type 2 respiratory failure
  • hypoxemic pulmonary edema
  • hypoxemis respiratory failure
  • advanced neuromusclar disorders (ALS)
    • require advanced nursing skills
    • can be burdensome
    • OPtion for withdrawal anytime
37
Q

Cough : function

A
  • Inspiratory phase: lengthening of expiratory muscles
  • Compression phase : against closed glottis, build up of intrathoracid pressure.
  • Expiratory phase : expel air at high velocity with compression of airway.
  • Cough protects airway by clearing inhaled materials, mucus, sputum
  • Effort is reduced:
    • cachexia
    • steroid myopathy
    • gross ascites
    • hepatomegaly
    • altered LOC
    • vocal cord paralysis
    • tumour
    • stent
    • altered mucous or mucociliary action in COPD, CF, chronic smokers
38
Q

Regulation of Cough

A
  • Modulated by vagal afferent pathways
    • rapidly adapting receptors (RARs) : activated by smoke, hypertonic saline –> bronchoconstriction
    • C fibres : capsaicin, bradykinin, acidity
    • Cough receptor : touch, acid
  • activation of vagal afferents depends on expression of ion channels:
    • TRP vanilloid (TRPV1)
      • capsaicin, acid, inflammatory mediators
    • TRP anakyrin (TRPA1)
      • cold, air pollution, cigarette smoke
    • calcium permeable, non selective cationic channels
  • Afferent sensory nerves synapse in nucleus solitarus in brainstem
  • Transmitted to cough centre –> coordinate cough reflex
39
Q

Causes of cough in palliative care

A

Cancer etiologies

  • Airway tumours
  • pleural involvement
  • pericardium
  • mediastinum
  • lymphangitic carcinomatosis
  • dysphagia
  • aspiration
  • hypersecretion of mucus

Non cancer causes:

  • COPD
  • Asthma
  • bronchiectasis
  • IPF
  • upper airway cough syndrome
  • GERD
  • Smoking
40
Q

Assessment of cough in palliative care:

A

History:

  • associated sputum
  • precipitating factors: smoking irritants, drugs, feeding, posture, timing of the day
  • Associated sx: dyspnea, insomnia, choking, fatigue
  • cancer treatment
  • ACE
  • chronic cardiac or lung conditions
  • validated scale for cough

Investigations (potential):

  • lung function tests
  • sputum culture
  • CXray
  • CT scan
  • SLP swallowing assessment
41
Q

Management of cough : treatment for cancer related causes

A
  • radiotherapy
  • chemotherapy (gemcitabine especially)
  • endobronchial therapy
  • Steroids for tumour edema, airway obstruction, lymphangitic carcinomatosis, radiation, immune therapy pneumonitis
  • Antibiotics with caution (resistance, ineffectiveness)
42
Q

Management of cough : non-cancer causes

A
  • discontinue ACE
  • Empiric treatment of common causes : AUC, rhinitis, GERD
  • antihistamine
  • decongestant
  • PPI
  • Bronchodilator
  • Possible steroids
43
Q

Anti-tussive medications : centrally acting

A
  • Centrally acting - opioids u receptors CNS
    • Increase dose of systemic opioids by 25-50% if already on
    • Morphine SR 5-10 mg bid.
      • (DB placebo controlled trial)
    • Hydrocodone -
      • codeine derivative with hydromorphone metabolite
    • Codeine -
      • CYP 450
      • prodrug metabolized to morphine.
      • RCT not more effective than placebo
      • 10-20 mg po q4h prn
    • Dextromethorphan (not recommended Up to Date)
      • non opioid, NMDA antagonist
      • 10-20 mg q4h prn
      • CYP 450 / CYP 2D6
    • Nebulized lidocaine for severe cases - no evidence
44
Q

Anti-tussive medications : peripherally acting

A
  • Sodium cromoglycate
    • 2 puffs bid
    • double blind rct significant reduction in cough
  • Levodropropizine (inhibits afferent pathways)
    • 75 mg po bid
  • Benzonatate (anesthetizes stretch receptors of vagal afferent fibres of alveoli, bronchi, pleura)
    • 100-200 mg po tid
  • Moguisteine ( MOA uncertain)
    • 100-200 mg po tid
    • as effective as codiene tid
  • Gabapentin/pregabalin
    • Recommended as second line if opioids not tolerated
    • best evidence for GERD cough
    • RCT for refractory cough improved cough scores
    • low dose 300 mg po od
45
Q

Approach to treating cough

A
  • Mild cough :
    • non pharm therapies
    • honey
    • breathing exercises
    • cough suppression techniques
    • patient counselling
    • peripherally acting meds
      • benzonatate
  • Moderate-severe cough
    • opioids first line
    • gabapentin/pregabalin second line
    • nebulized lidocaine
46
Q

Airway secretions

A
  • Mucociliary clearance
    • hypersecretion in inflammatory diseases like COPD, infection
    • hypertrophy of goblet cells and submucosal cells
    • loss of ciliary function
    • destruction of surfactant
    • alteration of mucus
    • purulence : neutrophils, f-actin, apoptotic cells, bacteria
  • Cough can clear higher viscosity secretions
  • Ciliary clearance works for lower viscosity secretions
47
Q

Mucoactive medications for secretions

A
  • increase ability to expectorate sputum or decrease mucus hypersecretion
  • Nebulized saline
  • Guafenesin (increases hydration of resp tract, reduces viscosity, inhibits cough reflex)
  • Carbocysteine (?mOA)
  • N-acetylcysteine : mucolytic, antioxidant , antiinflammatory
    • 400-1200 mg/day
    • nebulized can cause bronchospasm, lack of evidence
48
Q

Bronchorrhoea : definition and pathophysiology

A
  • production of > 100 mL of water sputum daily (average 25 ml)
  • Causes:
    • bronchioalveloar carcinoma
    • metastatic cancer
    • Chronic bronchitis
    • asthma
    • bronchiectasis
  • hypoxia, dyspnea, exhaustion, chest pain, functional decline, social limitation
  • treat disease, radiotherapy, macrolides, anticholinergics, octreotide, steroids, indomethacine, tyrosine kinase inhibitors
49
Q

Noisy airway secretions at end of life

A
  • positioning
  • gentle oral suction, but not deep suctioning
  • discontinue IV fluids
  • Glycopyrrolate 0.2-0.4 mg sc q4h prn
    • fewer central effects, no BBB
  • Scopalamine hyoscine butylbromide (antimuscarinic)