Dyslipidemia Flashcards
A patient was just started on Lipitor 20mg daily. According to the ACC/AHA guidelines, when should the lipid panel be checked?
4-12 weeks
A patient is admitted to the hospital with an acute myocardial infarction. Which statin regimen, when initiated immediately, has been shown to improve short term outcomes by reducing the risk of recurrent ischemia?
High-intensity statin therapy initiated within 96 hours of hospitalization for an acute coronary syndrome has been shown to reduce the incidence of recurrent ischemia. The statin and regimen used in these studies (MIRACL and PROVE-IT TIMI 22) was atorvastatin 80 mg daily and this is the only high-intensity regimen listed.
Which of the following are other names of niacin? B1, B2, B3, Biotin, Nicotinic Acid
B3 and nicotinic acid
Which 3 statins undergo first pass metabolism and by what CYP enzyme?
Simvastatin, lovastatin and atorvastatin, 3A4
What effect does gemfibrozil have on lipids?
Increase and decrease LDL, increase HDL and decrease TG’s (If TG’s are really high, LDL can actually be increased by fibrates)
Which of the following are true concerning lomitapide?
A
It is contraindicated in pregnancy
B
It has a boxed warning for renal toxicity
C
It is indicated for homozygous familial hypercholesterolemia
D
It has a boxed warning for hepatotoxicity
E
Enrollment in REMS program is not required
It is contraindicated in pregnancy (Cat X), It is indicated for homozygous familial hypercholesterolemia and ithas a BBW for hepatotoxicity.
Which lipid lowering drug class is contraindicated in patients with a history of gallstones?
Fibrates
Adjunct to diet, Myalept is indicated to treat:
A: Hypertriglyceridemia without congenital or acquired generalized lipodystrophy
B: Leptin deficiency with congenital or acquired generalized lipodystrophy
C: Leptin deficiency without congenital or acquired generalized lipodystrophy
D: HIV-related dystrophy
E: Metabolic disease
B: Leptin deficiency with congenital or acquired generalized lipodystrophy
Which dyslipidemia agent can increase TG’s?
Bile acid sequestrants
Which statin is the least potent?
Fluvastatin
How should Welchol tablets be administered?
With a meal and liquid
What is the correct mechanism of action of fenofibrates?
A: Fenofibrates inhibit the enzyme HMG-CoA reductase.
B: Fenofibrates bind to bile acids in the gut.
C: Fenofibrates reduce cholesterol absorption at the brush-border.
D: Fenofibrates are peroxisome proliferator alpha activators.
E: Fenofibrates bind to and inhibit microsomal triglyceride transfer protein (MTP) in the endoplasmic reticulum.
D: Fenofibrates are peroxisome proliferator alpha activators
Which of the following dosing regimens would be appropriate for a patient using niacin immediate-release?
Niacin immediate-release must be started very slowly or it will not be tolerated. Niacin extended-release (Niaspan) is started at 500 mg QHS x 4 weeks (after a light snack), followed by 1,000 mg QHS x 4 weeks, can increase to 2,000 mg QHS. The maximum dose of this formulation is 2 grams daily, versus 3 grams daily for the immediate-release, according to the ACC/AHA guidelines.
Which medications could contribute to lipid panel abnormalities?
A: Ambien
B: Hydrochlorothiazide
C :Levothyroxine
D: Prenatal vitamin
E: None of her medications are associated with lipid abnormalities.
Thiazides are associated with increases in LDL and triglycerides. Loop diuretics can cause increases in triglycerides and total cholesterol.
Which lipid lowering therapy is contraindicated in a patient with active peptic ulcer disease?
A: Crestor B: Niaspan C: Tricor D: Zetia E: Omtryg
Niacin
