DSA: Acute Infectious Diarrhea Flashcards
Acute infectious diarrhea is the of the most infectious causes of death in the world. Most patients die due to ________.
Dehydration
Etiologies of acute infectious diarrhea and Sx
-
Bacterial toxins or bacteria that make enterotoxins
- => small bowel hypersecretion
- Abrupt profuse watery diarrhea and vomitting a few hours after ingestion
- Fever: minimal to none
- => small bowel hypersecretion
-
Entero-adherent pathogens
- More cramping and bloating and less vomitting
- Fever: high
-
Invasive microorganisms that make cytotoxins
- Fever: high
- Abdominal pain
How will a pathogen that affects the small bowel persent?
- Large amounts of watery diarrhea + cramps that can lead to dehydration and malabsorption.
- Cramos occur in mid-abdomen or are diffuse
- No WBC in stool (non-inflammatory)
How will a pathogen that affects the large bowel present?
- Frequent, small amounts of bloody stool (dysentary) due to inflammation + fever and fecal leukocytes.
- Location: lower abdomen or rectum
- Enterotoxins (non- inflammatory) pathogens affect the ____________, causing _____ diarrhea.
- Inflammatory (invasive or cytotoxins) pathogens affect the __________, causing ______ diarrhea.
- Penetrating pathogens affect the __________, causing _________.
- Proximal SB; watery
- Distal SB or colon; dysentary or inflammatory diarrhea
- Distal SB; enteric fever
What do we see in stool findings for these pathogens?
- Non-inflammatory (enterotoxins)
- Inflammatory (invasive or cytotoxin)
- Penetrating
- No fecal leukocytes; mild or NO increase in fecal lactoferrin
- Fecal PNM leukocytes; increase in fecal lactoferrin
- Fecal mononuclear leukocytes
2 Penetrating Pathogens
- Salmonella Typi
- Y. Enterocolitica
High risk groups for acute infectious diarrhea
- Travels
- Immunodeficient people
- Daycare workers/bbs/family
- Instutionalized ppl (nursing home, hospitals)
- Consuming certain foods
Daycare workers/ bbs and families are more susceptible to
- Shigella
- Giardia
- Crytosporidium
- Rotavirus
PE for patients with acute infectious diarrhea
- Fever, hypotension, tachycardia
- Dehydration
- Increased bowel sound
Decreased or absent bowel sounds =>
- Post-op ileus
- Toxic megacolon
Signs of mild, moderate and severe dehydration
Mild:
- Thirst, dry mouth, ↓ sweat / urine output and slight weight loss
Moderate
- Orthostatic fall in blood pressure, skin tenting, sunken eyes (infants = sunken fontanelle)
Severe:
- Lethargy, obtundation, feeble pulse, hypotension, frank shock
Acute Infectious Diarrhea
- ________ transmission and most cases are ________.
- Fecal - oral transmission
- Mild and self-limited, thus, does not need work-up
1st thing to do when a patient presents with acute diarrhea, no matter if mild, moderate or severe is to ___________.
Fluid and electrolyte replacement
In acute Infectious Diarrhea, diarrhea is self-limited and does not need workup. However, what are a few indications for work-ups?
- Profuse diarrhea (6 or more times a day) with dehydration
- Fever above 101 (38.5), hypotension and tachycardia that does not respond to volume repletion
- Dysentary (bloody diarrhea with leukocytes)
- Recent ABX uses (check for c.diff)
- Creatinine is more than 1.5x baseline or peripheral leukocytes is more than 15,000.
What do you perform upon workup of Acute Infectious Diarrhea?
- CBC, electrolytes, BUN/Cr, blood culture
______ is the cornerstone of diagnosing Acute Infectious Diarrhea.
Stool culture
Routine bacterial stool culture tests for
- Salmonella
- Shigella
- E. coli
- Campylobactor (most)
What stool bacterial cultures must be requested?
- Shiga-like toxin detection for 0157:H7 EHEC (enterohemorrhagic e.coli)
- Vibrio
- Yersenia
What other labs may you need to ask for?
- Stool immunoassay PCR/toxin for C.diff
- Ova and parasites
- Stool protzoa antigen (giardia, cyrptosporidium, E. histolytica)
- Stool viral PCR/antigen (rotavirus, Norwalk/norovirus)
- Fecal leukocytes (inflammtory causes)
- Fecal lactoferrin (enzyme in leukocytes => inflammatory)
In Acute Infectious Diarrhea, if stool studies are unrevealing, perform a _________.
Endoscopy
Radiology requests for Acute Infectious Diarrhea
-
Abdominal XR (plain)
- detects free intraperitoneal air and checks for ileus/toxic megacolon
-
Abdominal CT with PO/IV contrast
- More sensitive for free air and IDs colitis
- Suspect food poisening in a patient when:
- Routine testing?
- Multiple illnesses are reproted after sharing food and in the summertime
- Routine testing is NOT done
Consumption of chicken is most associated with
- Salmonella
- Campylobacter
- Shigells


